Are stem-cell therapies for parkinson’s disease ready for clinical trials?

Are stem-cell therapies for parkinson's disease ready for clinical trials?
As stem cell-based therapies are moving rapidly towards clinical trials, treatments for Parkinson’s Disease (PD), an incurable condition, may be on the horizon. A recent announcement of a Phase I/IIa clinical trial involving transplantation of stem cells into the first human subjects has raised hope among patients and sparked discussions in the research community.

Stem cell infusion could be effective for most common type of heart failure

Stem cell infusion could be effective for most common type of heart failure
Formerly known as diastolic heart failure, the diagnosis now called heart failure with preserved ejection fraction is a condition in which the heart muscle becomes so stiff that its pumping chambers cannot properly fill with blood. Even though the heart’s ability to pump blood to the body remains normal, its inability to fill with blood over time can lead to fluid buildup. This affects other...

Research offers hope for better treatments for retinal degenerative diseases

Research offers hope for better treatments for retinal degenerative diseases
The above post is reprinted from materials provided by Medical University of South Carolina. Note: Materials may be edited for content and length. Cite This Page: Credit: Brennan Wesley, Medical University of SC This is a representation of vision as experienced by someone with macular degeneration. Close Medical University of South Carolina. (2016, February 24). Research offers hope for better...

Testing the power of stem cell-derived heart muscle cells

Testing the power of stem cell-derived heart muscle cells
Stem cell-derived cardiomyocytes have weaker contractile strength than their biological counterparts isolated from heart tissue. The findings could help explain critical shortcomings of stem cell-derived heart muscle cells in clinical trials.

Muscles on-a-chip provide insight into cardiac stem cell therapies

Muscles on-a-chip provide insight into cardiac stem cell therapies
Stem cell-derived heart muscle cells may fail to effectively replace damaged cardiac tissue because they don’t contract strongly enough, according to a new study. This may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.

Stem cell study paves the way for patient therapies

Stem cell study paves the way for patient therapies
Stem cells that have been specifically developed for use as clinical therapies are fit for use in patients, an independent study of their genetic makeup suggests. The research — which focused on human embryonic stem cells — paves the way for clinical trials of cell therapies to treat conditions such as Parkinson’s disease, age-related degeneration of the eyes and spinal cord injury....

Cardiac muscle cells as good as progenitors for heart repair

Cardiac muscle cells as good as progenitors for heart repair
Stem cell therapies for post-heart attack tissue repair have had modest success at best. Clinical trials have primarily used bone marrow cells, which can promote the growth of new blood vessels, but many studies have shown no benefit. A better alternative may be to use human heart muscle cells (cardiomyocytes), suggests a new study.

New drug for blood cancers now in five phase II clinical trials

New drug for blood cancers now in five phase II clinical trials
The safety and dosing of a new drug for treating blood cancers has now been established by a group of scientists. The drug is a small molecule inhibitor that suppresses the activity of a signaling pathway believed to contribute to a variety of blood cancers’ eventual resistance to standard chemotherapy treatments.

New anti-cancer stem cell compound in development

New anti-cancer stem cell compound in development
Dr Robert Clarke, from the University of Manchester’s Institute of Cancer Sciences, said: “This is an exciting development from a Cardiff team that is expert in the mechanics of regulating cell death. The drug that they have developed appears to target cancer stem cell activity, which suggests it will prevent metastatic recurrence and be useful in combatting drug resistance.” The...

Stem cells that prevent birth defect also repair facial injury

Stem cells that prevent birth defect also repair facial injury
Until now, the surgeons had unknowingly destroyed the regenerative stem cells when operating on craniosynostosis patients. Within weeks, researchers noticed that the Gli1+ stem cells were migrating to repair injured areas of the skull. Researchers plan to conduct additional experiments before the treatment is tested in clinical trials with patients. The above story is based on materials provided by...