Gene therapy restores immune function in children with rare immunodeficiency

Gene therapy restores immune function in children with rare immunodeficiency
An investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to new research. The researchers found that 48 of 50 children who received the gene therapy retained their replenished immune system function two to three years later and did not require additional treatments for their condition,...

Scientists reveal how brain cells in Alzheimer’s go awry, lose their identity

Scientists reveal how brain cells in Alzheimer's go awry, lose their identity
Despite the prevalence of Alzheimer’s, there are still no treatments, in part because it has been challenging to study how the disease develops. Now, scientists have uncovered new insights into what goes awry during Alzheimer’s by growing neurons that resemble — more accurately than ever before — brain cells in older patients. And like patients themselves, the afflicted neurons...

New ‘time machine’ technique to measure cells

New 'time machine' technique to measure cells
Using a new single-cell technique, researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. The research uncovered new genes that program stem cells to make the dendritic cells that kick-start the immune response. By uncovering this process, the researchers hope they will be able to find new immunotherapy treatments for cancer, and plan to expand...

Scientists use nanotechnology to detect bone-healing stem cells

Scientists use nanotechnology to detect bone-healing stem cells
Researchers have developed a new way of using nanomaterials to identify and enrich skeletal stem cells — a discovery which could eventually lead to new treatments for major bone fractures and the repair of lost or damaged bone.

Cellular benefits of gene therapy seen decades after treatment

Cellular benefits of gene therapy seen decades after treatment
Researchers have shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.

Double trouble for drug-resistant cancers

Double trouble for drug-resistant cancers
New research identifies chemotherapy-resistant cancers’ escape mechanism, which offers new anti-cancer treatment options.

Treatment for type-2 diabetic heart disease

Treatment for type-2 diabetic heart disease
Researchers have discovered one of the reasons why more than 50 per cent of people with type 2 diabetes die from heart disease. And perhaps more significantly, they have found a way to treat it.

Single cell sequencing opens new avenues for eradicating leukemia at its source

Single cell sequencing opens new avenues for eradicating leukemia at its source
Cancer stem cells that elude conventional treatments like chemotherapy drive long-term cancer growth and relapse. These cells are difficult to isolate and study because of their low abundance and similarity to other stem cells. Researchers have created a new method that can distinguish cancer stem cells, mature cancer cells and otherwise healthy stem cells based on their genetics and gene expression....

Researchers identify mechanisms that are essential for proper skin development

Researchers identify mechanisms that are essential for proper skin development
Latest discovery could improve development of future stem cell therapies and cancer treatments.

Unlocking the mystery behind skeletal aging

Unlocking the mystery behind skeletal aging
Researchers have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million people worldwide. Findings could hold an important key to developing more effective treatments for osteoporosis and improving the lives of an aging population....