Researchers discover key stem cell dormancy mechanism which could help unlock future cancer treatments

Researchers discover key stem cell dormancy mechanism which could help unlock future cancer treatments
Researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.

Stem cells can use same method as plants and insects to protect against viruses

Stem cells can use same method as plants and insects to protect against viruses
Researchers have found a vital mechanism, previously thought to have disappeared as mammals evolved, that helps protect mammalian stem cells from RNA viruses such as SARS-CoV-2 and Zika virus. The scientists suggest this could one day be exploited in the development of new antiviral treatments.

Muscles retain positional memory from fetal life

Muscles retain positional memory from fetal life
Muscles and the resident stem cells (satellite cells) responsible for muscle regeneration retain memory of their location in the body. This positional memory was found to be based on the expression pattern of the homeobox (Hox) gene cluster, which is responsible for shaping the body during fetal life. These findings are expected to provide clues to elucidate the pathogenesis of muscle diseases like...

Sleeper cells: Newly discovered stem cell resting phase could put brain tumors to sleep

Sleeper cells: Newly discovered stem cell resting phase could put brain tumors to sleep
Biomedical engineering researchers developed a new cell classifier tool that takes a higher-resolution look at the life cycle of neuroepithelial stem cells, which led to the discovery and exploration of a new resting phase called Neural G0. This knowledge could help scientists to better understand glioma brain tumors and develop new methods of treatment.

Stem cell scientists make big progress in building mini-kidneys

Stem cell scientists make big progress in building mini-kidneys
Researchers have created what could be a key building block for assembling a synthetic kidney. They describe how they generate rudimentary kidney structures, known as organoids, that resemble the collecting duct system that helps maintain the body’s fluid and pH balance by concentrating and transporting urine. The organoids provide a way to study kidney disease that could lead to new treatments...

Gene therapy restores immune function in children with rare immunodeficiency

Gene therapy restores immune function in children with rare immunodeficiency
An investigational gene therapy can safely restore the immune systems of infants and children who have a rare, life-threatening inherited immunodeficiency disorder, according to new research. The researchers found that 48 of 50 children who received the gene therapy retained their replenished immune system function two to three years later and did not require additional treatments for their condition,...

Scientists reveal how brain cells in Alzheimer’s go awry, lose their identity

Scientists reveal how brain cells in Alzheimer's go awry, lose their identity
Despite the prevalence of Alzheimer’s, there are still no treatments, in part because it has been challenging to study how the disease develops. Now, scientists have uncovered new insights into what goes awry during Alzheimer’s by growing neurons that resemble — more accurately than ever before — brain cells in older patients. And like patients themselves, the afflicted neurons...

New ‘time machine’ technique to measure cells

New 'time machine' technique to measure cells
Using a new single-cell technique, researchers have uncovered a way to understand the programming behind how stem cells make particular cell types. The research uncovered new genes that program stem cells to make the dendritic cells that kick-start the immune response. By uncovering this process, the researchers hope they will be able to find new immunotherapy treatments for cancer, and plan to expand...

Scientists use nanotechnology to detect bone-healing stem cells

Scientists use nanotechnology to detect bone-healing stem cells
Researchers have developed a new way of using nanomaterials to identify and enrich skeletal stem cells — a discovery which could eventually lead to new treatments for major bone fractures and the repair of lost or damaged bone.

Cellular benefits of gene therapy seen decades after treatment

Cellular benefits of gene therapy seen decades after treatment
Researchers have shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.