Nanoparticle for overcoming leukemia treatment resistance

Nanoparticle for overcoming leukemia treatment resistance
One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. A research team found that repurposing a commonly used chemotherapy drug using a nanoparticle was more effective than both a solution of the pure drug and other available treatments.

Primitive stem cells point to new bone grafts for stubborn-to-heal fractures

Primitive stem cells point to new bone grafts for stubborn-to-heal fractures
Although most broken bones can be mended with a firm cast and a generous measure of tender loving care, more complicated fractures require treatments like bone grafting. Researchers have now created superior bone grafts using primitive stem cells. They found that these cells help create very fertile scaffolds needed for bone to regenerate at the site of repair.

Cord blood for stem cell transplant may outperform matched sibling donor

Cord blood for stem cell transplant may outperform matched sibling donor
Study based on a decade of research and treatment shows no difference in overall survival between cord blood and matched related donor as source for stem cell transplant, with reduced graft-versus-host disease in patients using cord blood.

Potential treatment for Rett Syndrome

Potential treatment for Rett Syndrome
An experimental cancer drug can extend the life of mice with Rett Syndrome, a devastating genetic disorder that afflicts about one of every 10,000 to 15,000 girls within 6 to 18 months after birth.

Stem cell treatments ‘go deep’ to regenerate sun-damaged skin

Stem cell treatments 'go deep' to regenerate sun-damaged skin
Some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they’ve been getting good results, it’s been unclear exactly how these treatments work to rejuvenate ‘photoaged’ facial skin. A new study finds that within a few weeks, stem cell treatment eliminates the sun-damaged elastin network and replacing them with normal, undamaged tissues and...

Unique insight into development of the human brain: Model of the early embryonic brain

Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers have designed a model of an early embryonic brain. The model will increase our understanding of how the human brain develops and can thereby help to accelerate the development of stem cell treatments for brain disorders such as Parkinson’s disease, epilepsy and dementia.

Image analysis technique provides better understanding of heart cell defects

Image analysis technique provides better understanding of heart cell defects
Many patients with heart disease face limited treatment options. Fortunately, stem cell biology has enabled researchers to produce large numbers of cardiomyocytes, which may be used in drug screens and cell-based therapies. However, current image analysis techniques don’t allow researchers to analyze heterogeneous, multidirectional, striated myofibrils typical of immature cells. Researchers showcase...

Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury

Scientists show MRI predicts the efficacy of a stem cell therapy for brain injury
Scientists have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury — a first-ever ‘biomarker’ for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve efficacy.

Researchers repurpose classic chemotherapy drug to overcome cancer therapy resistance

Researchers repurpose classic chemotherapy drug to overcome cancer therapy resistance
Drug resistance is a major obstacle in cancer treatment — leading to relapse for many patients. In a new study, researchers report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.

Abnormal bone formation after trauma explained and reversed in mice

Abnormal bone formation after trauma explained and reversed in mice
Nw study findings implicate a specific type of immune cell behind heterotopic ossification, or abnormal bone formation and present a possible target for treatment.