Silencing retroviruses to awaken cell potential

Silencing retroviruses to awaken cell potential
Silencing of retroviruses in the human genome is a crucial step in the production of induced pluripotent stem cells (iPSCs) from somatic cells. Researchers led by a team from the University of Tsukuba have now identified a protein that controls retrovirus silencing, allowing the production of high quality iPSCs that could be used in applications ranging from stem cell therapy and organ regeneration...

Stem cell therapy helps broken hearts heal in unexpected way

Stem cell therapy helps broken hearts heal in unexpected way
A study shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to...

Researchers discover how cells know their future and forget their past

Researchers discover how cells know their future and forget their past
All cells in the body contain the same genetic material. The difference between cells therefore depends solely on which genes are expressed or ‘turned on’. Now, researchers have gained new insights into how genes are turned on and off and how the cells ”forget their past” while developing into a specific cell in the body. This new knowledge will be crucial for stem cell therapy...

Novel dual stem cell therapy improving cardiac regeneration

Novel dual stem cell therapy improving cardiac regeneration
Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.

Stem cell therapy furthers research for infants with hypoplastic left heart syndrome

Stem cell therapy furthers research for infants with hypoplastic left heart syndrome
A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant’s own stem cells directly into the heart at the time of surgery.

Intranasal stem cell therapy restores smell in mice

Intranasal stem cell therapy restores smell in mice
A stem cell therapy delivered into the nose can restore the sense of smell in a mouse model of olfactory loss. The findings provide proof of principle for an approach that has the potential to be of broad utility for a range of clinical conditions causing loss of olfaction.

Surprising research result: All immature cells can develop into stem cells

Surprising research result: All immature cells can develop into stem cells
A new study challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells’ surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy.

Advance stem cell therapy with biodegradable scaffold

Advance stem cell therapy with biodegradable scaffold
Scientists have created a tiny, biodegradable scaffold to transplant stem cells and deliver drugs, which may help treat Alzheimer’s and Parkinson’s diseases, aging brain degeneration, spinal cord injuries and traumatic brain injuries. Stem cell transplantation, which shows promise as a treatment for central nervous system diseases, has been hampered by low cell survival rates, incomplete...

Stem cell therapy drug may protect against smoke-related COPD symptoms

Stem cell therapy drug may protect against smoke-related COPD symptoms
A drug used in stem cell therapy to treat certain cancers may also protect against cigarette smoke-induced lung injury.

Stem cell therapy may help reverse effects of premature menopause, restore fertility

Stem cell therapy may help reverse effects of premature menopause, restore fertility
Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests.