Transforming skin cells to insulin

Transforming skin cells to insulin
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Popular stem cell techniques deemed safe; unlikely to pass on cancer-causing mutations

Popular stem cell techniques deemed safe; unlikely to pass on cancer-causing mutations
A new study shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients.

New stem cell research uncovers causes of spinal muscular atrophy

New stem cell research uncovers causes of spinal muscular atrophy
New research has used pioneering stem cell techniques to better understand why certain cells are more at risk of degenerating in Spinal Muscular Atrophy than others.

Human stem cells used to reveal mechanisms of beta-cell failure in diabetes

Human stem cells used to reveal mechanisms of beta-cell failure in diabetes
Nov. 13, 2013 ? Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute and Columbia University Medical Center (CUMC) have used stem cells created from the skin of patients with a rare form of diabetes — Wolfram syndrome — to elucidate an important biochemical pathway for beta-cell failure in diabetes. The findings by Linshan Shang and colleagues were published today...

Researchers demonstrate use of stem cells to analyze causes, treatment of diabetes

Researchers demonstrate use of stem cells to analyze causes, treatment of diabetes
When given a glucose tolerance test three months later, mice with MODY beta cells had decreased sensitivity to glucose but a normal response to other molecules that stimulate insulin secretion. This is the hallmark of MODY. Mice with two faulty copies of the GCK gene secreted no additional insulin in response to glucose. When the researchers repaired the GCK mutation using molecular techniques, cells...