Experimental arthritis drug prevents stem cell transplant complication

Experimental arthritis drug prevents stem cell transplant complication
An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows. Studying mice, the researchers found the drug prevented what’s known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body’s own organs or tissues.

Phase III clinical trials for stem cell-based cartilage regeneration therapy have started

Phase III clinical trials for stem cell-based cartilage regeneration therapy have started
A group of researchers developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies.

Stem-cell researchers solve mystery of relapse in acute myeloid leukemia

Stem-cell researchers solve mystery of relapse in acute myeloid leukemia
Story Source: “These new kinds of biomarkers will lead to new kinds of clinical trials with targeted chemotherapy. Right now, everybody gets one size fits all because in AML we’ve never had any opportunity to identify patients upfront, only after they relapse. Now we have the first step to identify these patients at the outset and during remission.” Dr. Dick says: “Our new...

Unique stem cells as a potential asthma treatment

Unique stem cells as a potential asthma treatment
Story Source: Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma). The study,...

Lab grown human colons change study of GI disease

Lab grown human colons change study of GI disease
To see how human GI tissues perform in a living organism — and to test their future therapeutic potential — the research team included collaborators from the Division of Surgery, led by Michael Helmrath, MD, a pediatric surgeon and director of the Surgical Research program. Frogs and Mice at Forefront Researchers report that following transplant, the human colonic organoids assumed the...

Revolutionary approach for treating glioblastoma works with human cells

Revolutionary approach for treating glioblastoma works with human cells
Researchers describe how human stem cells, made from human skin cells, can hunt down and kill human brain cancer, a critical and monumental step toward clinical trials — and real treatment.

Avoiding mixtures of different mitochondria leads to effective mitochondrial replacement

Avoiding mixtures of different mitochondria leads to effective mitochondrial replacement
Scientists have discovered an important biological phenomenon in human cells that will help scientists design safer treatments to prevent mitochondrial diseases. The team first pioneered a technique, mitochondrial replacement therapy (MRT), in 2012 to prevent inheritance of these devastating and debilitating diseases. Now they are working to hone this technique and understand the biological processes...

Bio-mimicry method developed for preparing, labeling stem cells

Bio-mimicry method developed for preparing, labeling stem cells
Researchers have developed a new method for preparing mesenchymal stem cells (MSCs) that not only leads to the production of more native stem cells, but also labels them with a FDA approved iron-oxide nanoparticle (Ferumoxytol). The technology could allow researchers to track the cells in vivo using magnetic resonance imaging (MRI) during preclinical and clinical trials.

Are stem-cell therapies for parkinson’s disease ready for clinical trials?

Are stem-cell therapies for parkinson's disease ready for clinical trials?
As stem cell-based therapies are moving rapidly towards clinical trials, treatments for Parkinson’s Disease (PD), an incurable condition, may be on the horizon. A recent announcement of a Phase I/IIa clinical trial involving transplantation of stem cells into the first human subjects has raised hope among patients and sparked discussions in the research community.

Stem cell infusion could be effective for most common type of heart failure

Stem cell infusion could be effective for most common type of heart failure
Formerly known as diastolic heart failure, the diagnosis now called heart failure with preserved ejection fraction is a condition in which the heart muscle becomes so stiff that its pumping chambers cannot properly fill with blood. Even though the heart’s ability to pump blood to the body remains normal, its inability to fill with blood over time can lead to fluid buildup. This affects other...