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Developing a treatment for vision loss through transplant of photoreceptor precursors
A recent study examining the therapeutic potential of photoreceptor precursors, derived from clinically compliant induced pluripotent stem cells (iPSC), has demonstrated the safety and therapeutic potential of clinically compliant iPSC-derived photoreceptor precursors as a cell replacement source for future clinical trials.
Review assesses stem cell therapy potential for treating preeclampsia
A review of using stem cells to treat preeclampsia, a dangerous condition in pregnancy, indicates that mesenchymal stem/stromal cells (MSCs), or their secreted vesicles, have the potential to be used as therapies that could progress to clinical trials.
Stem cell therapy helps broken hearts heal in unexpected way
A study shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to...
Experimental arthritis drug prevents stem cell transplant complication
An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research shows. Studying mice, the researchers found the drug prevented what’s known as graft-versus-host disease, a debilitating, sometimes lethal condition that develops when transplanted stem cells attack the body’s own organs or tissues.
Phase III clinical trials for stem cell-based cartilage regeneration therapy have started
A group of researchers developed a synthetic tissue using synovium-derived mesenchymal stem cells (MSCs) for treating damaged cartilage, which had previously been incurable and had no effective therapies.
Stem-cell researchers solve mystery of relapse in acute myeloid leukemia
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“These new kinds of biomarkers will lead to new kinds of clinical trials with targeted chemotherapy. Right now, everybody gets one size fits all because in AML we’ve never had any opportunity to identify patients upfront, only after they relapse. Now we have the first step to identify these patients at the outset and during remission.”
Dr. Dick says: “Our new...
Unique stem cells as a potential asthma treatment
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Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma).
The study,...
Lab grown human colons change study of GI disease
To see how human GI tissues perform in a living organism — and to test their future therapeutic potential — the research team included collaborators from the Division of Surgery, led by Michael Helmrath, MD, a pediatric surgeon and director of the Surgical Research program.
Frogs and Mice at Forefront
Researchers report that following transplant, the human colonic organoids assumed the...
Revolutionary approach for treating glioblastoma works with human cells
Researchers describe how human stem cells, made from human skin cells, can hunt down and kill human brain cancer, a critical and monumental step toward clinical trials — and real treatment.
Avoiding mixtures of different mitochondria leads to effective mitochondrial replacement
Scientists have discovered an important biological phenomenon in human cells that will help scientists design safer treatments to prevent mitochondrial diseases. The team first pioneered a technique, mitochondrial replacement therapy (MRT), in 2012 to prevent inheritance of these devastating and debilitating diseases. Now they are working to hone this technique and understand the biological processes...