Damaged muscles don’t just die, they regenerate themselves

Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate ”satellite cells,” which are muscle stem cells. While attempting to identify the activating proteins, they found that metabolic enzymes, such as GAPDH, rapidly activated quiescent satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism, in which the damaged muscle itself activates satellite cells for regeneration.

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