Potential liver cancer treatment by targeting cancer stem-like cells

Potential liver cancer treatment by targeting cancer stem-like cells
Researchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.

Treatment for ‘low T’ could someday come from a single skin cell

Treatment for 'low T' could someday come from a single skin cell
Researchers have successfully grown human, testosterone-producing cells in the lab, paving the way to someday treat low testosterone with personalized replacement cells.

Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin

Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin
In a proof-of-concept study, researchers have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Additionally, the nanometer-sized exosomes can be delivered to the target cells via needle-free injections.

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

Alzheimer's disease risk gene APOE4 impairs function of brain immune cells
A study carried out with a new human stem cell-derived model reveals that the most prevalent genetic risk factor of Alzheimer’s disease (AD), apolipoprotein E4 (APOE4), impairs the function of human brain immune cells, microglia. These findings pave the way for new, effective treatment approaches for AD.

The neurobiological mechanisms behind schizophrenia may depend on gender

The neurobiological mechanisms behind schizophrenia may depend on gender
The neurobiological pathophysiology of schizophrenia differs significantly between males and females, according to a new study. The findings suggest a possible need for more sex-specific treatments for schizophrenia. The study was the first to identify a number of sex-specific genes related to schizophrenia using neurons derived from induced pluripotent stem cells.

Mini kidneys grown from stem cells give new insights into kidney disease and therapies

Mini kidneys grown from stem cells give new insights into kidney disease and therapies
Medical researchers have grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. These kidney organoids were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease. This method has paved the way for tailoring treatment plans specific to each patient, which could...

Scientists reverse aging process in rat brain stem cells

Scientists reverse aging process in rat brain stem cells
Scientists say the results have far reaching implications for how we understand the aging process, and how we might develop much-needed treatments for age-related brain diseases.

Novel dual stem cell therapy improving cardiac regeneration

Novel dual stem cell therapy improving cardiac regeneration
Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.

A new method of tooth repair? Scientists uncover mechanisms to inform future treatment

A new method of tooth repair? Scientists uncover mechanisms to inform future treatment
Stem cells hold the key to wound healing, as they develop into specialized cell types throughout the body — including in teeth. Now an international team of researchers has found a mechanism that could offer a potential novel solution to tooth repair.

Researchers make immunotherapy work for treatment-resistant lymphoma

Researchers make immunotherapy work for treatment-resistant lymphoma
Researchers have developed a way to use immunotherapy drugs against treatment-resistant non-Hodgkin’s lymphomas for the first time by combining them with stem cell transplantation, an approach that also dramatically increased the success of the drugs in melanoma and lung cancer.