Vital step in stem cell growth revealed

Vital step in stem cell growth revealed
When they looked closer at the genes that both pathways activated, researchers were surprised to find that the pathways were further connected to a third process, which is known to control tissue growth and organ size. The central protein in this new pathway, called Yap, acted specifically at these genes to counteract the effects of the Activin. The researchers found that Wnt loads up the cellular...

Stem cells that prevent birth defect also repair facial injury

Stem cells that prevent birth defect also repair facial injury
Until now, the surgeons had unknowingly destroyed the regenerative stem cells when operating on craniosynostosis patients. Within weeks, researchers noticed that the Gli1+ stem cells were migrating to repair injured areas of the skull. Researchers plan to conduct additional experiments before the treatment is tested in clinical trials with patients. The above story is based on materials provided by...

US clinics avoiding government oversight of ‘stem cell’ treatments

US clinics avoiding government oversight of 'stem cell' treatments
The above story is based on materials provided by Elsevier Health Sciences. Note: Materials may be edited for content and length. “These clinics aren’t going to stop making these marketing claims and performing procedures just because the FDA has issued three new draft guidance documents,” Dr. Turner cautioned. “It is going to take a substantial effort by the FDA to address...

Scientists identify key receptors behind development of acute myeloid leukemia

Scientists identify key receptors behind development of acute myeloid leukemia
The Zhang laboratory studies the roles of immune inhibitory receptors in stem cells and cancer. Dr. Zhang hopes to understand the molecular mechanisms that govern the fates of adult stem cells and cancer cells, and apply this knowledge to the development of new cell and antibody therapies for treating cancer and other diseases. Story Source: Researchers found that some receptors containing the immunoreceptor...

Prenatal stem cell treatment improves mobility issues caused by spina bifida

Prenatal stem cell treatment improves mobility issues caused by spina bifida
Farmer was senior author of the landmark Management of Myelomeningocele Study (MOMS), which showed that prenatal surgery could improve cognitive outcomes for the 1,500 children born each year in the U.S. with spina bifida. A majority of treated children in the study, however, were unable to walk independently at 30 months of age. The lower-limb paralysis associated with spina bifida may be effectively...

Stem-cell-based therapy promising for treatment of breast cancer metastases in the brain

Stem-cell-based therapy promising for treatment of breast cancer metastases in the brain
Investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study published online in the journal Brain also describes a strategy of preventing the potential negative consequences...

Cell-assisted lipotransfer: Safety not demonstrated

Cell-assisted lipotransfer: Safety not demonstrated
Story Source: The above story is based on materials provided by Deutsches Aerzteblatt International. Note: Materials may be edited for content and length. The authors consider it a critical problem that the oncological risks of stem-cell treatment are still unclear. The similarity of stem cells to cancer cells makes safety a major concern that requires careful study. The long-term effects of cell-assisted...

Link between proteins points to possibilities for future Alzheimer’s treatments

Link between proteins points to possibilities for future Alzheimer’s treatments
The research was funded by Alzheimer’s Research UK and the Wellcome Trust. The scientists, from the University of Cambridge, found that as a protein called amyloid precursor protein (APP) is broken down into toxic protein fragments called amyloid-beta, it affects changes in the way that another key protein, tau, behaves. Though links between these proteins have been described in earlier work,...

New drug combination shows promise for breaking breast cancer resistance

New drug combination shows promise for breaking breast cancer resistance
While most women initially respond well to hormonal treatment with drugs such as tamoxifen, many go on to develop resistance and relapse. There is evidence that this is often due to activation of the Wnt signalling pathway, a gene involved in development which fuels the growth of the tumour. The above story is based on materials provided by Manchester University. Note: Materials may be edited for...

First stem cell-based approach to treat type 2 diabetes effective in mice

First stem cell-based approach to treat type 2 diabetes effective in mice
“Success in these clinical trials could pave the way for testing in patients with type 2 diabetes,” Kieffer says. “Our hope is that a stem cell-based approach to insulin replacement will ultimately improve glucose control in patients with both type 1 and type 2 diabetes, resulting in healthier, longer lives.” First, they fed mice a high-fat diet to induce obesity, low responsiveness...