Proper stem cell function requires hydrogen sulfide

Proper stem cell function requires hydrogen sulfide
Professor Songtao Shi, principal investigator on the project, said the presence of hydrogen sulfide produced by the cells governs the flow of calcium ions. The essential ions activate a chain of cellular signals that results in osteogenesis, or the creation of new bone tissue, and keeps the breakdown of old bone tissue at a proper level. Story Source: Stem cells in bone marrow need to produce hydrogen...

Transcription factors distinguishing glioblastoma stem cells identified

Transcription factors distinguishing glioblastoma stem cells identified
“This study brings us back to the fundamental idea that there are many reasons that cancer cells can be aggressive,” explains senior author Bradley Bernstein, MD, PhD, of MGH Pathology and the MGH Cancer Center. “Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different...

Bone marrow stem cells show promise in stroke treatment

Bone marrow stem cells show promise in stroke treatment
The analysis appears in the April 8 issue of Neurology. Importantly, the effects of these cells on functional recovery were robust regardless of the dosage, the time the MSCs were administered relative to stroke onset or the method of administration. (The cells helped even if given a month after the event and whether introduced directly into the brain or injected via a blood vessel.) In an earlier...

Light-activated neurons from stem cells restore function to paralyzed muscles

Light-activated neurons from stem cells restore function to paralyzed muscles
Story Source: In the study, published this week in Science, the team demonstrated the method in mice in which the nerves that supply muscles in the hind legs were injured. They showed that the transplanted stem cell-derived motor neurons grew along the injured nerves to connect successfully with the paralyzed muscles, which could then be controlled by pulses of blue light. “We custom-tailored...

Patient stem cells help identify common problem in ALS

Patient stem cells help identify common problem in ALS
The ALS hyperexcitability was further examined by Woolf’s team, led by Harvard Medical School neurologist Brian Wainger, MD, PhD. Working with Eggan and Kiskinis collectively, they found a cyclical relationship between the increased neuron activity and abnormal protein folding. In the two papers, they describe how the overexcitable ALS neurons generate more abnormally folded proteins, further...

Cell-surface receptor offers promising breakthrough for pancreatic cancer patients

Cell-surface receptor offers promising breakthrough for pancreatic cancer patients
“We now know that a small group of pancreatic cancer stem cells are responsible for re-growing a tumor after therapy,” he said. “These stem cells are hardy and difficult to kill. Therefore, even if the bulk of the tumor has been killed after treatment, the pancreatic cancer stem cells remain and will eventually regrow a tumor and may even migrate to a different location in the body...

Major breakthrough in stem cell manufacturing technology

Major breakthrough in stem cell manufacturing technology
The research, “Combined hydrogels that switch human pluripotent stem cells from self-renewal to differentiation“ is published in the Proceedings of the National Academy of Sciences (PNAS). “Our new combination of hydrogels is a first. It allows dense tissue structures to be produced from human pluripotent stem cells (HPSC) in a single step process never achieved before. The discovery...

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle

New human trial shows stem cells are effective for failing hearts: Bone marrow-derived stem cells injected directly into heart muscle
Story Source: Although there are other therapies available for patients with ischemic heart disease, these therapies do not help all patients and many patients continue to face fatigue, shortness of breath and accumulation of fluid in the lungs and legs. The study also supports findings from previous, smaller studies, which showed reduced scar tissue in the hearts of patients who received the stem...

Preserving fertility in boys with cancer: New study shows promise

Preserving fertility in boys with cancer: New study shows promise
Even when ALL cells made up 40 percent of the cell mixture being cultured, they were entirely eliminated in 26 days of culture. The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length. Sadri-Ardekani performed the work with researchers at the University of Amsterdam and Avicenna Research Institute in Tehran, Iran, before...

‘Mini heart’ invented to help return venous blood

'Mini heart' invented to help return venous blood
Story Source: The novel approach of creating ‘mini hearts’ may help to solve a chronic widespread disease. Chronic venous insufficiency is one of the most pervasive diseases, particularly in developed countries. Its incidence can reach 20 to 30 percent in people over 50 years of age. It is also responsible for about 2 percent of health care costs in the United States. Additionally, sluggish...