Researchers develop novel treatment to prevent graft-versus-host-disease

Researchers develop novel treatment to prevent graft-versus-host-disease
Graft-versus-host-disease (GVHD) is the leading cause of non-relapse associated death in patients who receive stem cell transplants. In a new study, researchers show that a novel treatment can effectively inhibit the development of GVHD in mice and maintain the infection- and tumor-fighting capabilities of the immune system.

Fertility: Out of gas and low on sperm?

Fertility: Out of gas and low on sperm?
Sperm are constantly replenished in the adult male body. Understanding the workings of stem cells responsible for this replenishment is expected to shed light on why male fertility diminishes with age, and possibly lead to new treatments for infertility.

Chinese herbal treatment shows signs of effectiveness in bone marrow recovery

Chinese herbal treatment shows signs of effectiveness in bone marrow recovery
A Chinese herbal regimen called TSY-1 (Tianshengyuan-1) TSY-1 increased Telomerase activity in normal blood cells but decreased it in cancer cells, research has demonstrated. Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division. These results indicate that Telomerase-based treatments may be of significance in treatments...

Stem cell ‘living bandage’ for knee injuries trialed in humans

Stem cell 'living bandage' for knee injuries trialed in humans
A ‘living bandage’ made from stem cells, which could revolutionize the treatment and prognosis of a common sporting knee injury, has been trialed in humans for the first time.

Therapy response in brain tumor cells is linked to disease prognosis

Therapy response in brain tumor cells is linked to disease prognosis
The brain tumor form glioblastoma is difficult to treat and has very poor prognosis. In a new study, scientists show that a type of stem cell in the tumor is present in different states, with different response to drugs and radiation. The results may open an avenue towards development of new treatment strategies designed to reverse therapy resistant cell states to more sensitive states.

Stem cell-based test predicts leukemia patients’ response to therapy to help tailor treatment

Stem cell-based test predicts leukemia patients' response to therapy to help tailor treatment
Leukemia researchers have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.

Genetic factors control regenerative properties of blood-forming stem cells

Genetic factors control regenerative properties of blood-forming stem cells
Two studies define how key genetic factors affect blood-forming stem cells by either accelerating or hindering the cells’ regenerative properties. The findings could one day lead to improved treatments for people undergoing common therapies for cancer such as chemotherapy and radiation, say researchers.

Leukemia drug combo is encouraging in early phase I clinical trial

Leukemia drug combo is encouraging in early phase I clinical trial
In a Phase I study, 8 out of 12 patients with relapsed and/or chemotherapy refractory blood cancers responded to a combination of the chemotherapy drugs thioguanine and decitabine; some of the responders had relapsed after treatment with decitabine alone, report researchers.

Preventative antibiotics could prevent Clostridium difficile infection among stem cell transplant patients

Preventative antibiotics could prevent Clostridium difficile infection among stem cell transplant patients
It may be possible to safely prevent one of the most common – and costly to treat – infections contracted by hospitalized patients undergoing bone marrow transplantation for the treatment of blood cancers, according to a new study.

New information on how brain cancer spreads

New information on how brain cancer spreads
Glioblastoma multiforme remains the most common and highly lethal brain cancer and is known for its ability to relapse. Researchers have identified a pathway by which cancer cells aggressively spread and grow in the brain, opening up new possibilities for treatment.