Potential ‘Achilles heel’ in brain cancer

Potential 'Achilles heel' in brain cancer
Scientists believe they have uncovered an ‘Achilles heel’ of glioblastoma multiforme (GBM), the most common and deadly form of brain cancer. Their study details how a mechanism that protects glioma stem cells can potentially be exploited to develop new and more effective treatments for GBM.

Researcher discovers mechanisms and epigenetic markers with implications for diseases ranging from cancers to infertility

Researcher discovers mechanisms and epigenetic markers with implications for diseases ranging from cancers to infertility
A researcher uncovered new mechanisms that dictate the development of germline stem cells. Mechanisms were found to be associated with genes responsible for cancers and viral infections among other major diseases. Markers used to identify male germ cells were discovered, exploring how environmental factors or epigenetics affect these cells and providing significant insight into treatments for male...

‘Incompatible’ donor stem cells cure adult sickle cell patients

'Incompatible' donor stem cells cure adult sickle cell patients
Doctors have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be incompatible, thanks to a new transplant treatment protocol.

New cell therapy aids heart recovery — without implanting cells

New cell therapy aids heart recovery -- without implanting cells
Medical researchers have designed a creative new approach to help injured hearts regenerate by applying extracellular vesicles secreted by cardiomyocytes rather than implanting the cells. The study shows that the cardiomyocytes derived from human pluripotent stem cells (derived in turn from a small sample of blood) could be a powerful, untapped source of therapeutic microvesicles that could lead to...

An index measures similarity between cancer cells and pluripotent stem cells

An index measures similarity between cancer cells and pluripotent stem cells
The new methodology measures tumor aggressiveness and the risk of relapse, helping doctors plan treatment.

Anemia: When cells fail to produce enough protein factories

Anemia: When cells fail to produce enough protein factories
Every day, stem cells in our bone marrow produce billions of new red blood cells. Any disruption in this process can result in serious disease. Researchers have succeeded in furthering our understanding of how blood cells are formed. Their insights into the molecular foundations of this process may help break new ground in the treatment of certain types of anemia.

Mesenchymal stem cell therapy: Holding promise for feline inflammatory diseases

Mesenchymal stem cell therapy: Holding promise for feline inflammatory diseases
Stem cell therapy is acknowledged as having great potential for the treatment of a variety of diseases in both people and animals. The use of bone marrow-derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow- and adipose-derived stem cells are being evaluated.

Personalized stem cell treatment may offer relief for multiple sclerosis

Personalized stem cell treatment may offer relief for multiple sclerosis
Scientists have shown in mice that skin cells re-programmed into brain stem cells, transplanted into the central nervous system, help reduce inflammation and may be able to help repair damage caused by multiple sclerosis (MS).

Versatile sensor against tumor initiating cells

Versatile sensor against tumor initiating cells
Researchers have developed the first fluorescent sensor to visualize TICs. Functional in lung, central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer cell cultures, this could become a useful tool for biopsy-free post-treatment assessment and anti-TIC drug development.

Scientists target glioma cancer stem cells, which could improve patient survival

Scientists target glioma cancer stem cells, which could improve patient survival
Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers have devised a strategy to treat these tumors by...