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Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory-based study. The work could potentially lead to more effective treatments for broken bones.
The difficulty in getting stem cells to mature into more adult-like heart cells has hindered the search for regenerative treatments for hearts damaged by disease. A molecular switch has now been discovered that appears to help embryonic heart cells switch from a glucose to fatty acid based metabolism, becoming larger, stronger, and acting like more mature heart cells. This discovery may lead to lab...
Cells dying as the result of radiation exposure or chemotherapy can send a warning to nearby stem cells or to tumor-initiating cells. The chemical signal allows both the tissue-repair cells and the tumor-forming cells to escape the same fate. This may explain why many cancers return after initially responding to treatment and could lead to new, more effective cancer drugs. These might block the warning...
The above story is based on materials provided by Gladstone Institutes. Note: Materials may be edited for content and length. Story Source: Instead of using stem cells themselves, the scientists extracted the proteins that the cells secrete–such as bone morphogenetic protein (BMP)–in order to harness their regenerative power. To do so, the researchers first treated stem cells with a chemical...
Dr Robert Clarke, from the University of Manchester’s Institute of Cancer Sciences, said: “This is an exciting development from a Cardiff team that is expert in the mechanics of regulating cell death. The drug that they have developed appears to target cancer stem cell activity, which suggests it will prevent metastatic recurrence and be useful in combatting drug resistance.” The...
The discovery that a single protein can exert such a global genomic function stems from recent advances in DNA sequencing technologies, which allow for the sequencing of a complex genome in just hours. “NextGen DNA sequencing allows us to analyze millions of DNA sequences selected by the interacting protein,” Stachowiak said. Sequencing advances “We’ve known that the human...
Published in the journal Oncogene, the researchers have for the first time shown how a specific protein receptor on the surface of breast cells promotes the progression of breast cancer. “In particular, it has been implicated in the growth and spread of breast cancer, but its function in breast cancer has not been clear. “Breast cancer is the most commonly diagnosed cancer in women worldwide...
When they looked closer at the genes that both pathways activated, researchers were surprised to find that the pathways were further connected to a third process, which is known to control tissue growth and organ size. The central protein in this new pathway, called Yap, acted specifically at these genes to counteract the effects of the Activin. The researchers found that Wnt loads up the cellular...
Until now, the surgeons had unknowingly destroyed the regenerative stem cells when operating on craniosynostosis patients. Within weeks, researchers noticed that the Gli1+ stem cells were migrating to repair injured areas of the skull. Researchers plan to conduct additional experiments before the treatment is tested in clinical trials with patients. The above story is based on materials provided by...
The above story is based on materials provided by Elsevier Health Sciences. Note: Materials may be edited for content and length. “These clinics aren’t going to stop making these marketing claims and performing procedures just because the FDA has issued three new draft guidance documents,” Dr. Turner cautioned. “It is going to take a substantial effort by the FDA to address...