Avoiding mixtures of different mitochondria leads to effective mitochondrial replacement

Avoiding mixtures of different mitochondria leads to effective mitochondrial replacement
Scientists have discovered an important biological phenomenon in human cells that will help scientists design safer treatments to prevent mitochondrial diseases. The team first pioneered a technique, mitochondrial replacement therapy (MRT), in 2012 to prevent inheritance of these devastating and debilitating diseases. Now they are working to hone this technique and understand the biological processes...

Stem cells from diabetic patients coaxed to become insulin-secreting cells

Stem cells from diabetic patients coaxed to become insulin-secreting cells
Signaling a potential new approach to treating diabetes, researchers have produced insulin-secreting cells from stem cells derived from patients with type 1 diabetes. The new discovery suggests a personalized treatment approach to diabetes may be on the horizon — one that relies on the patients’ own stem cells to manufacture new cells that make insulin.

Benefits of stem cells for treating spinal cord injuries assessed

Benefits of stem cells for treating spinal cord injuries assessed
Stem cell therapy is a rapidly evolving and promising treatment for spinal-cord injuries. According to a new literature review, different types of stem cells vary in their ability to help restore function, and an ideal treatment protocol remains unclear pending further clinical research.

Gene therapy shows early success against ‘Bubble Boy’ disease

Gene therapy shows early success against 'Bubble Boy' disease
Early results suggest novel gene therapy is safe and effective for treatment of inherited immune disease, according to scientists. The study involved five males with X-linked severe combined immunodeficiency disease (SCID-X1), also known as “Bubble Boy” disease. This inherited disorder involves a mutation in the IL2RG gene that affects males and occurs in 1 of every 50,000 to 100,000 live...

Recycling an anti-hypertensive agent to fight brain tumors

Recycling an anti-hypertensive agent to fight brain tumors
Treatments available for glioblastoma — malignant brain tumors — have little effect. An international collaboration tested active ingredients from existing medications and eventually identified one compound of interest, prazosin, on these tumors. Not only did it seem to be effective in this type of cancer, but it also acted on a signaling pathway that is common with other cancers.

Clues to improving wound healing

Clues to improving wound healing
A plant-based polyphenol promotes the migration of Mesenchymal Stem Cells (MSCs) in blood circulation and accumulates them in damaged tissues to improve wound healing, scientists have found. It is anticipated that the results will be used for stem cell treatments for cutaneous disorders associated with various damage and lesions.

Drug target found in rare, lethal glandular cancer

Drug target found in rare, lethal glandular cancer
Using a novel cell culture approach, researchers have discovered critical vulnerabilities in adenoid cystic carcinoma (ACC), a rare and lethal glandular cancer with a high recurrence rate and few treatment options.

Cellular trojan horse yields potential cancer treatment

Cellular trojan horse yields potential cancer treatment
A collaborative study has found proof-of-concept evidence for a potential cancer treatment that leverages microparticles and mesenchymal stem cells.

Preliminary study: Antibody therapy reduces cancer stem cells in multiple myeloma

Preliminary study: Antibody therapy reduces cancer stem cells in multiple myeloma
An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to new results.

Test run finds no cancer risk from stem cell therapy

Test run finds no cancer risk from stem cell therapy
The research followed the whole journey iPS cells would take when used in clinical therapy and found that iPs cells acquire 10 times fewer mutations than cells in the body and that no mutations occurred in genes known to cause cancer. The findings suggest that iPS cells do not pose a risk if used in regenerative treatment.