Aggressiveness of acute myeloid leukemia elucidated

Aggressiveness of acute myeloid leukemia elucidated
Scientists have discovered why acute leukemias with the same genetic abnormality vary in their aggressiveness based on their cellular origin. They found that the cancer inducing alteration is particularly devastating if it occurs in early hematopoietic stem cells expressing certain genes involved in cell migration and tissue invasion. These findings should now make it possible to classify patients...

Finding new clues to a sugar suspect in birth defects

Finding new clues to a sugar suspect in birth defects
Other researchers had shown that GLUT2 also can transport glucosamine, but whether GLUT2 functions as a glucosamine transporter under normal conditions has not been demonstrated. Dr. Loeken thought that embryo cells may need to obtain glucosamine from the mother’s circulation. To examine the role of glucosamine, which can’t be effectively adjusted in live animals, the Loeken lab created...

Regenerative medicine offering new treatment for bronchopleural fistulas

Regenerative medicine offering new treatment for bronchopleural fistulas
For the first time in human application, researchers successfully closed an open wound on the upper chest caused by postoperative complications of lung removal. The protocol and approach were based on an ongoing trial investigating this method to treat anal fistulas in Crohn’s disease.

New procedure allows long-term culturing of adult stem cells

New procedure allows long-term culturing of adult stem cells
A new procedure may revolutionize the culturing of adult stem cells. The approach has successfully generated and expanded airway stem cells from the sorts of samples collected during routine treatment of lung disorders and may be applicable to several other tissue types, including skin and the linings of the gastrointestinal and reproductive tracts.

Antibody-based drug helps ‘bridge’ leukemia patients to curative treatment

Antibody-based drug helps 'bridge' leukemia patients to curative treatment
In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants.

Stem cells from umbilical cord blood may help treat eczema

Stem cells from umbilical cord blood may help treat eczema
A new study suggests that treatment with stem cells from umbilical cord blood might be an effective therapy for patients with moderate-to-severe eczema, or atopic dermatitis. For the clinical trial, 34 patients were randomly assigned to receive a low dose or high dose of the cells subcutaneously. Fifty five percent of patients who received the high dose showed a 50% reduction in what’s known as the...

Dual stem-cell transplant improves outlook for children with high-risk neuroblastoma

Dual stem-cell transplant improves outlook for children with high-risk neuroblastoma
Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical trial has found. The tandem transplant technique produced even better results when followed by treatment with immunotherapy agents.

New insights into muscular dystrophy point to potential treatment avenues

New insights into muscular dystrophy point to potential treatment avenues
Certain stem cells in our bodies have the potential to turn into either fat or muscle. Experiments in mice suggest prospective drugs that manipulate these cells’ fate could make it possible to relieve many of the symptoms of muscular dystrophy.

Team identifies gene involved with fracture healing

Team identifies gene involved with fracture healing
New identification of a gene involved in the fracture healing process could lead to the development of new therapeutic treatments for difficult-to-heal injuries, report scientists.

New muscular dystrophy drug target identified

New muscular dystrophy drug target identified
Muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair, scientists have discovered. This finding provides a new target for potential drug treatments for the disease, which currently has no cure.