New protocol to generate intestinal organoids in vitro

New protocol to generate intestinal organoids in vitro
Researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system. Using human induced pluripotent stem cells, this novel approach combined a variety of techniques that enabled the development of three-dimensional groups of intestinal cells called organoids...

Recurrent miscarriage: Diabetes drug could lead to new treatment

Recurrent miscarriage: Diabetes drug could lead to new treatment
A drug designed to tackle diabetes could also be repurposed as the first treatment to prevent miscarriage by targeting the lining of the womb itself, according to a clinical trial.

Immune outposts inside kidney tumors predict post-surgery outcomes

Immune outposts inside kidney tumors predict post-surgery outcomes
Patients with well-supported immune cells in their tumors are more likely to control their cancers’ growth for a longer time, an observation that could guide treatment decisions after surgery for kidney cancer. In addition, the findings could help researchers expand the dramatic but sparse benefits of cancer immunotherapy to more people.

Protein could offer therapeutic target for pancreatic cancer

Protein could offer therapeutic target for pancreatic cancer
A protein that drives growth of pancreatic cancer, and which could be a target for new treatments, has been identified.

When added to gene therapy, plant-based compound may enable faster, more effective treatments

When added to gene therapy, plant-based compound may enable faster, more effective treatments
Today’s standard process for administering gene therapy is expensive and time-consuming — a result of the many steps required to deliver the healthy genes into the patients’ blood stem cells to correct a genetic problem. Scientists believe they have found a way to sidestep some of the current difficulties, resulting in a more efficient gene delivery method that would save money and...

Viagra shows promise for use in bone marrow transplants

Viagra shows promise for use in bone marrow transplants
Researchers have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor. Bone marrow transplants, used mostly in the treatment of cancer, are life-saving procedures to restore the stem cells that generate new blood cells throughout a person’s life.

Potential liver cancer treatment by targeting cancer stem-like cells

Potential liver cancer treatment by targeting cancer stem-like cells
Researchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.

Treatment for ‘low T’ could someday come from a single skin cell

Treatment for 'low T' could someday come from a single skin cell
Researchers have successfully grown human, testosterone-producing cells in the lab, paving the way to someday treat low testosterone with personalized replacement cells.

Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin

Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin
In a proof-of-concept study, researchers have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Additionally, the nanometer-sized exosomes can be delivered to the target cells via needle-free injections.

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

Alzheimer's disease risk gene APOE4 impairs function of brain immune cells
A study carried out with a new human stem cell-derived model reveals that the most prevalent genetic risk factor of Alzheimer’s disease (AD), apolipoprotein E4 (APOE4), impairs the function of human brain immune cells, microglia. These findings pave the way for new, effective treatment approaches for AD.