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Tremendous progress in development of skin stem cell treatments for butterfly children
Before the repaired fibroblasts could be reintroduced into the organism, measures to prevent inflammation or rejection were necessary. In this study the researchers conducted a type of “toxicity test,” and the results were very promising. After several months of observation, no adverse immune reactions occurred, and the risk of skin cancer did not increase. That is an important consideration...
Scientists identify bone cells that could help children who need corrective facial surgery
Ono said one of the challenges in the bone and cartilage field is that stem cells haven’t really been identified. The only widely accepted idea is that certain stem cells help bones grow and heal, but that’s only discussed in the context of adults with bone disorders such as osteoporosis.
Our bones are smart. Bones know that by adolescence it’s time to stop growing longer and stronger,...
Gene therapy cure for children with ‘bubble baby’ disease
The groundbreaking treatment was developed by renowned stem cell researcher and UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Donald Kohn, whose breakthrough was developed over three decades of research to create a gene therapy that safely restores immune systems in children with ADA-deficient SCID using the patient’s own cells with no side effects.
“I...
Efficacy of new drug against stem cells that provoke onset, growth of cancer, metastasis
Researchers are currently conducting safety tests and they expect that this new drug, as well as its derivatives, can be run through clinical tests with actual patients in the near future.
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An Andalusian team of researchers led by the University of Granada has demonstrated the efficacy of a new drug against cancerogenic stem cells, which cause the onset and development of cancer, of relapse...
Muscle relaxant may be viable treatment for rare form of diabetes
The above story is based on materials provided by Washington University School of Medicine. The original article was written by Jim Dryden. Note: Materials may be edited for content and length.
The drug, dantrolene, prevents the destruction of insulin-producing beta cells both in animal models of Wolfram syndrome and in cell models derived from patients who have the illness.
Urano and his team of...
New ways to drain cancer’s ‘fuel tank’ discovered
Nell Barrie, senior science information manager at Cancer Research UK, said: “Blocking cancer cells’ ability to generate the energy they need to grow and divide is an exciting new avenue for future cancer treatments. This research suggests that MCT inhibitors may be particularly effective against breast cancer ‘stem cells’ that can resist other treatments, and could prevent...
Signaling molecule crucial to stem cell reprogramming
“WNT signaling is ubiquitous,” said Willert. “Every cell expresses one or more WNT genes and every cell is able to receive WNT signals. Individual cells in a dish can grow and divide without WNT, but in an organism, WNT is critical for cell-cell communication so that cells distinguish themselves from neighbors and thus generate distinct tissues, organs and body parts.”
To their...
Molecular time signalling controls stem cells during brain’s development
“This is the first known signalling molecule that regulates the potential of neuronal stem cells,” says Johan Ericson. “With a better understanding of how potential is regulated, it could be possible to broaden the development spectrum of aging stem cells, allowing them to regain their capacity to produce cell types from earlier development stages, which in the long-term perspective...
Anti-leukemia drug may also work against ovarian cancer
“ROR1 is used by embryo cells to migrate and to develop new organs,” said Kipps. “Cancer stem cells subsequently use ROR1 for their own growth and dissemination throughout the body. They are essentially the seeds of the cancer. The more seeds a tumor has, the greater its ability to recur after therapy or metastasize.”
Kipps said the results reaffirm the idea that at least some...
Brain injuries in mice treated using bone marrow stem cells, antioxidants
Researchers of CEU Cardenal Herrera University (CEU-UCH) for the first time transplanted bone marrow stem cells into damaged brain tissue while applying lipoic acid (a potent antioxidant), with the aim of improving neuroregeneration in the tissue. This new way of repairing brain damage, which combines cellular treatment with drug therapy, has shown positive results, especially in forming blood vessels...