Common virus may help inform treatment planning for stem cell transplant patients

Common virus may help inform treatment planning for stem cell transplant patients
A genetic relationship has been found between the reactivation of the human cytomegalovirus and the onset of graft-versus-host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

Vulnerability identified for subtypes of glioblastoma

Vulnerability identified for subtypes of glioblastoma
Glioblastoma, the most common and aggressive form of brain cancer, typically fails to respond to treatment or rapidly becomes drug resistant. Researchers have now identified a strategy that pinpoints a genetically distinct subpopulation of patients with glioblastoma that is particularly sensitive to drugs like cilengitide that target a specific cell adhesion receptor.

Brain cell advance brings fresh hope for Creutzfeldt-Jakob disease therapies

Brain cell advance brings fresh hope for Creutzfeldt-Jakob disease therapies
Scientists have developed a new system to study Creutzfeldt-Jakob disease in the laboratory, paving the way for research to find treatments for the fatal brain disorder.

Paraplegic rats walk and regain feeling after stem cell treatment

Paraplegic rats walk and regain feeling after stem cell treatment
Paralyzed rats implanted with engineered tissue containing human stem cells were able to walk independently and regained sensory perception in their hind legs and tail. The implanted rats also show some degree of healing in their spinal cords. The research demonstrates the great potential of stem cells to treat spinal cord injury.

Stem cells pave the way for new treatment of diabetes

Stem cells pave the way for new treatment of diabetes
A new stem cell study shows how we may increase the vital production of insulin in patients suffering from diabetes. The discovery helps to more efficiently at less cost make insulin-producing beta cells from human stem cells. Therefore, the research paves the way for more effective treatment of diabetes. The method may also prove significant to the treatment of a series of other diseases.

Inflammation trains the skin to heal faster

Inflammation trains the skin to heal faster
Stem cells in the skin remember an injury, helping them close recurring wounds faster, researchers have found. The discovery could advance research and treatment of psoriasis and other inflammatory diseases.

Bolstering fat cells offers potential new leukemia treatment

Bolstering fat cells offers potential new leukemia treatment
Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, says a new study. Researchers found that boosting adipocytes, or fat cells, located in the bone morrow suppressed cancerous leukemia cells but — in a surprise to the research team — also induced the regeneration of healthy blood cells.

Scientists pinpoint surprising origin of melanoma

Scientists pinpoint surprising origin of melanoma
A team of researchers has tracked down the cellular origin of cutaneous melanoma, the deadliest form of skin cancer. The team was surprised to observe that these very aggressive tumors arise from mature, pigment-producing cells called melanocytes. As melanoma develops, these cells are eventually reprogrammed, lose their differentiated features and become invasive, migratory cancer cells. This knowledge...

New type of stem cell line produced offers expanded potential for research and treatments

New type of stem cell line produced offers expanded potential for research and treatments
Researchers have created expanded potential stem cells (EPSCs) in mice, for the first time, that have a greater potential for development than current stem cell lines. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell.

Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells

Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells
For the first time, research shows that glioblastoma (GBM) is driven by two distinct subsets of cancer stem cells. Moreover, each subtype of glioma stem cells is driven by distinct transcriptional programs for growth and treatment resistance. The subsets also responded better to combination treatment in the mouse model.