The bull’s eye: New modified stem cells can deliver drugs specifically to tumor cells

The bull's eye: New modified stem cells can deliver drugs specifically to tumor cells
Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability. Now, researchers have successfully modified MSCs to deliver large quantities of anti-cancer...

Cutting edge technology to bioprint mini-kidneys

Cutting edge technology to bioprint mini-kidneys
Researchers have used cutting edge technology to bioprint miniature human kidneys in the lab, paving the way for new treatments for kidney failure and possibly lab-grown transplants.

World’s first: Drug guides stem cells to desired location, improving their ability to heal

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy — a scientific first and major advance for the field of regenerative medicine.

Stem cell transplantation: Undesirable rejection mechanism identified

Stem cell transplantation: Undesirable rejection mechanism identified
In the treatment of leukemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions – especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers has now identified an immune mechanism that is partially responsible...

Langerhans cells are up to the job, they just need a chance

Langerhans cells are up to the job, they just need a chance
Researchers found that Langerhans cells (LCs) play a crucial role in mucocutaneous acute guest-versus-host disease (aGVHD). Their experiments in mice showed that when the LCs of a recipient were depleted, the formation of mucocutaneous lesions was enhanced because the infiltration of CD8+ T cells was inhibited. Their findings have significant implications for improving blood stem cell transplantation...

Exosome treatment improves recovery from heart attacks in a preclinical study

Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mixture of heart muscle cells, endothelial cells and smooth muscle cells — which were all derived from human induced pluripotent stem cells — yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells.

Stem cells can repair Parkinson’s-damaged circuits in mouse brains

Stem cells can repair Parkinson's-damaged circuits in mouse brains
Researchers demonstrated a proof-of-concept stem cell treatment in a mouse model of Parkinson’s disease. They found that neurons derived from stem cells can integrate well into the correct regions of the brain, connect with native neurons and restore motor functions.

Breakthrough for tomorrow’s dentistry

Breakthrough for tomorrow's dentistry
New knowledge on the cellular makeup and growth of teeth can expedite developments in regenerative dentistry – a biological therapy for damaged teeth – as well as the treatment of tooth sensitivity.

Placenta is initiated first, as cells of a fertilized egg divide and specialize

Placenta is initiated first, as cells of a fertilized egg divide and specialize
The first stages of placental development take place days before the embryo starts to form in human pregnancies. The finding highlights the importance of healthy placental development in pregnancy, and could lead to future improvements in fertility treatments such as IVF, and a better understanding of placental-related diseases in pregnancy.

A new discovery in regenerative medicine

A new discovery in regenerative medicine
Researchers have made an unexpected world-first stem cell discovery that may lead to new treatments for placenta complications during pregnancy.