Scientists identify gene vital for rebuilding intestine after cancer treatment

Scientists identify gene vital for rebuilding intestine after cancer treatment
A rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9, researchers have discovered.

New drug for blood cancers now in five phase II clinical trials

New drug for blood cancers now in five phase II clinical trials
The safety and dosing of a new drug for treating blood cancers has now been established by a group of scientists. The drug is a small molecule inhibitor that suppresses the activity of a signaling pathway believed to contribute to a variety of blood cancers’ eventual resistance to standard chemotherapy treatments.

Opening the door to the cause of myeloid leukemia: Finding the targets of common mutation

Opening the door to the cause of myeloid leukemia: Finding the targets of common mutation
Professor Peter Cockerill, of the University of Birmingham, explained: “We found that the mutated FLT3 protein always sends the same signals to the same set of genes in all AML patients that have this mutation. By finding out which signals and genes are the targets, we now have new targets that will allow us to attack this pathway.” Researchers at the University of Birmingham have made...

Prostate cancer: Scientists discover why some tumous are resistant to radiotherapy

Prostate cancer: Scientists discover why some tumous are resistant to radiotherapy
It is hoped that this new development could pave the way for more effective treatments — allowing a lower dose of radiotherapy to be used while prolonging the lives of thousands of men. In the latest studies, published in European Urology and the British Journal of Cancer, scientists in The YCR Cancer Research Unit in the Department of Biology at York have shown a direct link between these tiny...

New material forges the way for ‘stem cell factories’

New material forges the way for 'stem cell factories'
If you experience a major heart attack the damage could cost you around five billion heart cells. Future stem cell treatments will require this number and more to ensure those cells are replaced and improve your chances of survival.

Stem cell therapy shows promise in small clinical trial for rare lung disease

Stem cell therapy shows promise in small clinical trial for rare lung disease
Promising results are coming out of the first clinical trial in the world of a genetically-enhanced stem cell therapy for pulmonary arterial hypertension. This rare and deadly disease mainly affects young women, and is characterized by very high pressure in the arteries supplying blood to the lungs. The trial was designed to test the feasibility and side effects of the experimental treatment in seven...

iPSCs show promise for kidney treatment

iPSCs show promise for kidney treatment
Renal progenitor cells derived from human iPS cells were shown to have therapeutic effects when transplanted into acute kidney injury model mice. The transplants resulted in a significant reduction of fibrosis, suggesting that they may have preventative measures against chronic kidney disease. The positive effects were attributed to the secretion of renoprotective factors. Using this iPS cell model...

First step toward gene therapy treatment of mitochondrial disease unlocked by scientists

First step toward gene therapy treatment of mitochondrial disease unlocked by scientists
The first critical step in developing novel gene and stem cell therapy treatments for patients with mitochondrial disease has been revealed by scientists. This breakthrough sets the stage for replacing diseased tissue in patients and opens the door to a world of regenerative medicine where doctors are able to treat human diseases that are currently incurable.

Study of gene mutations in aplastic anemia may help optimize treament

Study of gene mutations in aplastic anemia may help optimize treament
Scientists have identified a group of genetic mutations in patients with aplastic anemia, which likely will help doctors optimize treatment for this rare and deadly blood condition. The study could lead to tailor-made treatment plans for aplastic anemia patients as part of the emerging precision medicine movement. It is the largest study of its kind to examine gene mutations in aplastic anemia, the...

Diabetic blindness: Best source of stem cells to block vision loss

Diabetic blindness: Best source of stem cells to block vision loss
Stem cells taken from donors are more likely to be more effective at battling diabetic retinopathy than cells taken from patients’ own bodies, a new study concludes. The work is a critical step toward the goal of injecting stem cells into patients’ eyes to stop or even reverse the vision loss. The findings also establish a crucial framework for evaluating stem cells to be used in potential...