When added to gene therapy, plant-based compound may enable faster, more effective treatments

When added to gene therapy, plant-based compound may enable faster, more effective treatments
Today’s standard process for administering gene therapy is expensive and time-consuming — a result of the many steps required to deliver the healthy genes into the patients’ blood stem cells to correct a genetic problem. Scientists believe they have found a way to sidestep some of the current difficulties, resulting in a more efficient gene delivery method that would save money and...

Viagra shows promise for use in bone marrow transplants

Viagra shows promise for use in bone marrow transplants
Researchers have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor. Bone marrow transplants, used mostly in the treatment of cancer, are life-saving procedures to restore the stem cells that generate new blood cells throughout a person’s life.

Potential liver cancer treatment by targeting cancer stem-like cells

Potential liver cancer treatment by targeting cancer stem-like cells
Researchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.

Treatment for ‘low T’ could someday come from a single skin cell

Treatment for 'low T' could someday come from a single skin cell
Researchers have successfully grown human, testosterone-producing cells in the lab, paving the way to someday treat low testosterone with personalized replacement cells.

Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin

Suntanner, heal thyself: Exosome therapy may enable better repair of sun, age-damaged skin
In a proof-of-concept study, researchers have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Additionally, the nanometer-sized exosomes can be delivered to the target cells via needle-free injections.

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

Alzheimer's disease risk gene APOE4 impairs function of brain immune cells
A study carried out with a new human stem cell-derived model reveals that the most prevalent genetic risk factor of Alzheimer’s disease (AD), apolipoprotein E4 (APOE4), impairs the function of human brain immune cells, microglia. These findings pave the way for new, effective treatment approaches for AD.

The neurobiological mechanisms behind schizophrenia may depend on gender

The neurobiological mechanisms behind schizophrenia may depend on gender
The neurobiological pathophysiology of schizophrenia differs significantly between males and females, according to a new study. The findings suggest a possible need for more sex-specific treatments for schizophrenia. The study was the first to identify a number of sex-specific genes related to schizophrenia using neurons derived from induced pluripotent stem cells.

Mini kidneys grown from stem cells give new insights into kidney disease and therapies

Mini kidneys grown from stem cells give new insights into kidney disease and therapies
Medical researchers have grown ‘miniature kidneys’ in the laboratory that could be used to better understand how kidney diseases develop in individual patients. These kidney organoids were grown outside the body from skin cells derived from a single patient who has polycystic kidney disease. This method has paved the way for tailoring treatment plans specific to each patient, which could...

Scientists reverse aging process in rat brain stem cells

Scientists reverse aging process in rat brain stem cells
Scientists say the results have far reaching implications for how we understand the aging process, and how we might develop much-needed treatments for age-related brain diseases.

Novel dual stem cell therapy improving cardiac regeneration

Novel dual stem cell therapy improving cardiac regeneration
Researchers have recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing hearts damaged by myocardial infarction, as an alternative to heart transplant.