Bolstering fat cells offers potential new leukemia treatment

Bolstering fat cells offers potential new leukemia treatment
Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, says a new study. Researchers found that boosting adipocytes, or fat cells, located in the bone morrow suppressed cancerous leukemia cells but — in a surprise to the research team — also induced the regeneration of healthy blood cells.

Scientists pinpoint surprising origin of melanoma

Scientists pinpoint surprising origin of melanoma
A team of researchers has tracked down the cellular origin of cutaneous melanoma, the deadliest form of skin cancer. The team was surprised to observe that these very aggressive tumors arise from mature, pigment-producing cells called melanocytes. As melanoma develops, these cells are eventually reprogrammed, lose their differentiated features and become invasive, migratory cancer cells. This knowledge...

New type of stem cell line produced offers expanded potential for research and treatments

New type of stem cell line produced offers expanded potential for research and treatments
Researchers have created expanded potential stem cells (EPSCs) in mice, for the first time, that have a greater potential for development than current stem cell lines. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell.

Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells

Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells
For the first time, research shows that glioblastoma (GBM) is driven by two distinct subsets of cancer stem cells. Moreover, each subtype of glioma stem cells is driven by distinct transcriptional programs for growth and treatment resistance. The subsets also responded better to combination treatment in the mouse model.

Keeping moving: Flat worms shed light on role of migrating stem cells in cancer

Keeping moving: Flat worms shed light on role of migrating stem cells in cancer
A new study has used flat worms to look at the role of migrating stem cells in cancer. Researchers used the worms (planarians) which are known for their ability to regenerate their tissues and organs repeatedly. By understanding how stem cells are programmed to move, what activates them and how they follow a correct path, researchers may be able to design new treatments for cancer.

Umbilical cord stem cells show promise as heart failure treatment

Umbilical cord stem cells show promise as heart failure treatment
Intravenous stem cell infusion derived from umbilical cords appears to boost heart muscle function in patients with heart failure, according to a small study. In this first-of-its-kind study, patients had ‘significant’ improvement in their hearts’ ability to pump blood and experienced no adverse side effects related to the therapy. The results suggest IV-infused umbilical cord-derived...

Getting to the heart of the matter: Nanogels for heart attack patients

Getting to the heart of the matter: Nanogels for heart attack patients
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New inhibitor brings new hope for aggressive triple receptor-negative breast cancer

New inhibitor brings new hope for aggressive triple receptor-negative breast cancer
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Improved stem cell transplantation therapies?

Improved stem cell transplantation therapies?
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Shortened telomeres linked to dysfunction in Duchenne muscular dystrophy, researchers find

Shortened telomeres linked to dysfunction in Duchenne muscular dystrophy, researchers find
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