Protein appears to protect against bone loss in arthritis

Protein appears to protect against bone loss in arthritis
Glucocorticoids and GILZ are both produced naturally in the body. Glucocorticoids are steroid hormones that help regulate the body’s use of the fuel glucose and dampen the immune response. “Our previous studies have shown that the GILZ transgenic mouse can make more bone,” said Dr. Nianlan Yang, MCG postdoctoral fellow. “We wanted to see if GILZ would still have a bone protective...

Non-toxic strategy to treat leukemia proposed by researchers

Non-toxic strategy to treat leukemia proposed by researchers
“One of the major hurdles for cancer therapy is that while the drugs are effective in killing cancer cells, they are toxic to normal cells,” said study first author Ying-Hua Wang, PhD, a postdoctoral fellow in the Scadden Lab. “In this study, we found a way to differentiate sensitivity between normal and malignant cells, suggesting a potential therapeutic angle.” A study comparing...

Neurochemical imbalance in schizophrenia discovered

Neurochemical imbalance in schizophrenia discovered
A comparison of neurotransmitters produced by the cultured “brain in a dish” neurons showed that the neurons derived from schizophrenia patients secreted significantly greater amounts of the catecholamine neurotransmitters dopamine, norepinephrine and epinephrine. “All behavior has a neurochemical basis in the brain,” Hook said. “This study shows that it is possible to...

Clinical trial to test safety of stem cell-derived therapy for type 1 diabetes

Clinical trial to test safety of stem cell-derived therapy for type 1 diabetes
The trial will assess the safety and efficacy of a new investigational drug called VC-01, which was recently approved for testing by the U.S. Food and Drug Administration. The 2-year trial will involve four to six testing sites, the first being at UC San Diego, and will recruit approximately 40 study participants. “The goal, first and foremost, of this unprecedented human trial is to evaluate...

Combining antibodies, iron nanoparticles and magnets steers stem cells to injured organs

Combining antibodies, iron nanoparticles and magnets steers stem cells to injured organs
“The result is a kind of molecular matchmaking,” Marb├ín said. “Through magnetic resonance imaging, we were able to see the iron-tagged cells traveling to the site of injury where the healing could begin. Furthermore, targeting was enhanced even further by placing a magnet above the injured heart.” The Cedars-Sinai Heart Institute has been at the forefront of developing investigational...

How stem cells can be used to treat lung disease

How stem cells can be used to treat lung disease
Story Source: Although inflammation is usually a method by which the body heals and copes with an infection, when the inflammation is dysregulated it can lead to severe damage. Immune cells known as macrophages can coordinate the inflammatory response by driving or suppressing inflammation, depending on the stimulation. They tested this in an animal model using human bone marrow-derived stem cells....

Researchers discover key to making new muscles

Researchers discover key to making new muscles
“Our next step is to see how long we can extend the cycling pattern, and test some of the STAT3 inhibitors currently in clinical trials for other indications such as cancer, as this could accelerate testing in humans,” added Sacco. STAT3 (signal transducer and activator of transcription 3) is a protein that activates the transcription of genes in response to IL-6, a signaling protein released...

Non-invasive method for diagnosing common, painful back condition being developed

Non-invasive method for diagnosing common, painful back condition being developed
An interdisciplinary research team in the Cedars-Sinai Biomedical Imaging Research Institute, Department of Biomedical Sciences, Regenerative Medicine Institute and Department of Surgery received a grant from the National Institutes of Health (NIH) to develop the first imaging technique used to identify biomarkers that could indicate patients have a painful, degenerative back condition. In the study,...

Rare stem cells hold potential for infertility treatments

Rare stem cells hold potential for infertility treatments
Infertility, which the Centers for Disease Control estimates affects as many as 4.7 million men in the United States, is a key complication of cancer treatments, such as chemotherapy and radiation therapy. “Unfortunately, many cancer treatments negatively impact fertility, and men who receive such treatments are at high risk of losing their fertility. This is of great concern among cancer patients,”...

Potential for ‘in body’ muscle regeneration, rodent study suggests

Potential for 'in body' muscle regeneration, rodent study suggests
Most tissues in the body contain tissue-specific stem cells that are believed to be the “regenerative machinery” responsible for tissue maintenance. It was these cells, known as satellite or progenitor cells, that the scientists wanted to mobilize. Next, the scientists will evaluate whether the regenerated muscle is able to restore function and will test clinical feasibility in a large...