Single gene encourages growth of intestinal stem cells, supporting ‘niche’ cells, and cancer

Single gene encourages growth of intestinal stem cells, supporting 'niche' cells, and cancer
A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study. The finding adds to evidence for the intimate link between stem cells and cancer, and advances prospects for regenerative medicine and cancer treatments.

Protection for the gut barrier: New approach may prevent graft-versus-host disease

Protection for the gut barrier: New approach may prevent graft-versus-host disease
Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s body. A team has identified molecular mechanisms that may protect patients against this dangerous response in the future. The key to preventing...

Protein primes mouse stem cells to quickly repair injury, study finds

Protein primes mouse stem cells to quickly repair injury, study finds
Potential therapy Normally, adult, tissue-specific stem cells are held in a kind of cellular deep freeze called quiescence to avoid unnecessary cell division in the absence of injury. In a 2014 paper published in Nature, Rodgers and Rando showed in laboratory mice that an injury to the muscle of one leg caused a change in the muscle stem cells of the other leg. These cells entered what the researchers...

Researchers improve technology to save sperm stem cells

Researchers improve technology to save sperm stem cells
Researchers have found a promising way to preserve sperm stem cells so boys could undergo cancer treatment without risking their fertility.

Stem cells help explain varied genetics behind rare neurologic disease

Stem cells help explain varied genetics behind rare neurologic disease
Researchers have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. They identified individual and shared defects in the cells that could inform treatment efforts.

Potential drugs and targets for brain repair

Potential drugs and targets for brain repair
Researchers have discovered drugs that activate signaling pathways leading to specific adult brain cell types from stem cells in the mouse brain, according to a new study. The results may open new avenues for drug development aimed at treatment of degenerative brain disorders.

Potential of stem cell therapy to repair lung damage

Potential of stem cell therapy to repair lung damage
A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of  patients.

Electroacupuncture releases stem cells to relieve pain, promote tissue repair, study finds

Electroacupuncture releases stem cells to relieve pain, promote tissue repair, study finds
A study led by Indiana University School of Medicine researchers demonstrates how electroacupuncture triggers a neurological mechanism that can help promote tissue repair and relieve injury-induced pain. “This work is a classic example of the power of team science, where investigators in different institutions with specific expertise worked together to unravel the complexity of how electroacupuncture...

Targeting a tumor trigger

Targeting a tumor trigger
Many cancer patients that receive chemotherapy go into remission at first, but relapse after treatment is discontinued. There is increasing evidence that this is due to the presence of cancer stem cells – cells that reproduce indefinitely and may seed new tumors. A research group has now devised a strategy to specifically target cancer stem cells in some cancers and reduce their tumor-generating...

Unproven stem cell ‘therapy’ blinds three patients at Florida clinic

Unproven stem cell 'therapy' blinds three patients at Florida clinic
Three people with macular degeneration were blinded after undergoing an unproven stem cell treatment that was touted as a clinical trial in 2015 at a clinic in Florida. Within a week following the treatment, the patients experienced a variety of complications, including vision loss, detached retinas and hemorrhage. They are now blind.