ALS research suggests stem cells be ‘aged’ to speed progress toward finding treatments

ALS research suggests stem cells be 'aged' to speed progress toward finding treatments
Scientists are seeking to build an improved stem-cell model of amyotrophic lateral sclerosis (ALS) to accelerate progress toward a cure for the devastating neurological disorder. Their findings demonstrate that current models can be enhanced by the aging of motor neurons to show how ALS damages cells later in life.

Protein found to bolster growth of damaged muscle tissue

Protein found to bolster growth of damaged muscle tissue
Biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could contribute to treatments for muscle degeneration caused by old age or muscular dystrophy.

Discovery of insulin-producing beta cell subtypes may impact diabetes treatment

Discovery of insulin-producing beta cell subtypes may impact diabetes treatment
Researchers have determined the existence of at least four separate subtypes of human insulin producing beta cells that may be important in the understanding and treatment of diabetes.

Surprising number of businesses selling unapproved stem cell ‘treatments’ in the US

Surprising number of businesses selling unapproved stem cell 'treatments' in the US
At least 351 companies across the United States are marketing unapproved stem cell procedures at 570 individual clinics. Such businesses advertise ‘stem cell’ interventions for orthopedic injuries, neurological disorders, cardiac diseases, immunological conditions, pulmonary disorders, injured spinal cords, and cosmetic indications. A stem cell researcher now presents an analysis of US...

Stem cell treatment for Lou Gehrig’s disease may be safe

Stem cell treatment for Lou Gehrig's disease may be safe
A phase II clinical trial in people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, suggests that transplanting human stem cells into the spinal cord may be done safely. While the study was not designed to determine whether the treatment was effective, researchers noted that it did not slow down the progression of the disease.

New method to grow and transplant muscle stem cells holds promise for treatment of muscular dystrophy

New method to grow and transplant muscle stem cells holds promise for treatment of muscular dystrophy
Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro. Researchers treated these stem cells with leukemia inhibitory factor, which effectively maintained the undifferentiated...

Aggressiveness of acute myeloid leukemia elucidated

Aggressiveness of acute myeloid leukemia elucidated
Scientists have discovered why acute leukemias with the same genetic abnormality vary in their aggressiveness based on their cellular origin. They found that the cancer inducing alteration is particularly devastating if it occurs in early hematopoietic stem cells expressing certain genes involved in cell migration and tissue invasion. These findings should now make it possible to classify patients...

Finding new clues to a sugar suspect in birth defects

Finding new clues to a sugar suspect in birth defects
Other researchers had shown that GLUT2 also can transport glucosamine, but whether GLUT2 functions as a glucosamine transporter under normal conditions has not been demonstrated. Dr. Loeken thought that embryo cells may need to obtain glucosamine from the mother’s circulation. To examine the role of glucosamine, which can’t be effectively adjusted in live animals, the Loeken lab created...

Regenerative medicine offering new treatment for bronchopleural fistulas

Regenerative medicine offering new treatment for bronchopleural fistulas
For the first time in human application, researchers successfully closed an open wound on the upper chest caused by postoperative complications of lung removal. The protocol and approach were based on an ongoing trial investigating this method to treat anal fistulas in Crohn’s disease.

New procedure allows long-term culturing of adult stem cells

New procedure allows long-term culturing of adult stem cells
A new procedure may revolutionize the culturing of adult stem cells. The approach has successfully generated and expanded airway stem cells from the sorts of samples collected during routine treatment of lung disorders and may be applicable to several other tissue types, including skin and the linings of the gastrointestinal and reproductive tracts.