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Changes in cellular metabolites, the simple compounds generated during life-sustaining chemical activities in cells, have been shown to regulate embryonic stem cell development at the earliest stages of life. The recent findings should improve scientists’ ability to use embryonic stem cells to grow new tissues and organs to replace those damaged by disease or injury. The findings also could lead...
Involving scientists from Griffith University’s Eskitis Institute for Drug Discovery, the Royal College of Surgeons in Ireland and University College Dublin, the research is published online in the journal Translational Psychiatry. “However, while on the surface this seems like a contradiction, the two studies support each other by showing that the regulation of protein synthesis is subtly...
It has been claimed that a treatment for female infertility will be available by stem cell therapy. But a new study questions whether new egg cells can be produced using stem cells.
Neural stem cells transplanted into damaged brain sites in mice dramatically improved both motor and cognitive impairments associated with dementia with Lewy bodies, according to neurobiologists.
Using mouse embryos, researchers have replicated the deterioration with aging of blood stem cells, particularly red blood cells, and were able to alleviate the fetal anemia suffered by the mouse embryos and prevent death in 40 percent of the cases. This is a first step towards the development of potential treatments for anemia caused by a deficient activity of these stem cells, such as the aplastic...
A research team reports progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment.
The cause of diabetic enteropathy has been discovered by researchers, along with a possible prevention and treatment strategy. The study demonstrates how diabetes can destroy the stem cells that maintain the intestinal lining–through excess production of a hormone called insulin-like growth factor binding protein 3 (IGFBP3).
For the past 27 years, cord blood transplants have been a life-saving treatment option for thousands of people with leukemia, non-Hodgkins lymphoma, Hodgkins disease and myelodysplastic disorders. Cord blood helps replace cancerous blood cells and replenish a patient’s own bone marrow and immune system. Researchers have now completed a pilot clinical trial that tested the use of hyperbaric oxygen...
A new explanation has been found as to why women with estrogen receptor positive (ER+) breast cancer develop resistance to hormone treatment, and a potential new approach to overcome the problem.
Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to researchers.