Versatile sensor against tumor initiating cells

Versatile sensor against tumor initiating cells
Researchers have developed the first fluorescent sensor to visualize TICs. Functional in lung, central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer cell cultures, this could become a useful tool for biopsy-free post-treatment assessment and anti-TIC drug development.

Scientists target glioma cancer stem cells, which could improve patient survival

Scientists target glioma cancer stem cells, which could improve patient survival
Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers have devised a strategy to treat these tumors by...

Study could explain link between high-cholesterol diet and colon cancer

Study could explain link between high-cholesterol diet and colon cancer
Scientists discovered that boosting mice’s cholesterol levels spurred intestinal stem cells to divide more quickly, enabling tumors to form 100 times faster. The study identifies a molecular pathway that could serve as a new drug target for colon cancer treatment.

Prader-Willi syndrome reversed in brain cells growing in the lab

Prader-Willi syndrome reversed in brain cells growing in the lab
Stem cell researchers have reversed Prader-Willi syndrome in brain cells growing in the lab. The discovery provides clues that could lead to a treatment for Prader-Willi, a genetic disorder that silences genes necessary for normal brain function. Prader-Willi occurs in about one out of every 15,000 births, and is the most common genetic cause of life-threatening childhood obesity.

Discovery may advance neural stem cell treatments for brain disorders

Discovery may advance neural stem cell treatments for brain disorders
New research reveals a novel gene regulatory system that may advance stem cell therapies and gene-targeting treatments for neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and mental health disorders that affect cognitive abilities.

Hedgehog signaling proteins keep cancer stem cells alive

Hedgehog signaling proteins keep cancer stem cells alive
Scientists have discovered that the survival of cancer stem cells is dependent on the ‘Hedgehog signaling pathway’. Targeting this pathway had previously shown no effect on the growth of colorectal cancer. Now, scientists have demonstrated that using different drugs to target a specific aspect of the pathway may yield better treatment outcomes for patients.

Scleroderma study: Hope for a longer life for patients with rare autoimmune disorder

Scleroderma study: Hope for a longer life for patients with rare autoimmune disorder
The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades.

‘Decorated’ stem cells could offer targeted heart repair

'Decorated' stem cells could offer targeted heart repair
‘Decorating’ cardiac stem cells with platelet nanovesicles can increase the stem cells’ ability to find and remain at the site of heart attack injury and enhance their effectiveness in treatment.

Stem cell transplant is better than drug therapy for scleroderma

Stem cell transplant is better than drug therapy for scleroderma
Scleroderma with internal organ involvement is a debilitating and lethal autoimmune disorder with few effective treatments. But a study has now found new cause for optimism using an aggressive stem cell transplant regimen.

In scientific first, IU researchers grow hairy skin in a dish

In scientific first, IU researchers grow hairy skin in a dish
Researchers have successfully developed a method to grow hairy skin from mouse pluripotent stem cells — a discovery that could lead to new approaches to model disease and new therapies for the treatment of skin disorders and cancers.