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In future work, the researchers will examine human esophageal tissues for evidence of stem cell dysfunction in Barrett’s esophagus disease. “The esophageal lining must renew regularly as cells slough off into the gastrointestinal tract,” said senior investigator Eric Lagasse, Pharm.D., Ph.D., associate professor of pathology, Pitt School of Medicine, and director of the Cancer Stem...
Cell discovery challenges dogma on how fetus develops; holds insights for liver cancer, regeneration
Beyond the womb, many human organs contain pools of partially differentiated stem cells, which are ready to differentiate into specific replacement cells as needed. Among these are stem cells that “know” they are liver cells, but have enough “stemness” to become more than one cell type. Story Source: Using standard tools of molecular biology, the team garnered evidence that...
“Embryonic stem cells have the potential to become any cell type in the body, but transplantation has been complicated by problems including the risk of teratoma formation and immune rejection,” explains lead author Professor Robert Lanza, Chief Scientific officer at Advanced Cell Technology in the USA. “As a result, immunoprivileged sites (that do not produce a strong immune response)...
Autophagy involves the engulfment of cellular organelles into specialized vacuoles surrounded by a double membrane. The contents of these vacuoles are delivered to the lysosome, another organelle within the cell, where they are degraded to useful small molecules and help to generate energy and biomass for the synthesis of macromolecules and new organelles. Researchers from Stanford University School...
Reporting their work in the journal Nature Biotechnology, the researchers said they had developed a potential therapy through the use of patient-specific induced pluripotent stem cells, which are normal adult cells that have been “coaxed” via laboratory techniques into reverting into the more primitive stem cells that can produce most types of bodily tissue. So, in one of the significant...
Giant leap for diabetes: From human embryonic stem cells to billions of human insulin producing cells
“We are now just one pre-clinical step away from the finish line,” said Melton, whose daughter Emma also has type 1 diabetes. Felicia W. Pagliuca, Jeff Millman, and Mads Gurtler of Melton’s lab are co-first authors on the Cell paper. The research group and paper authors include a Harvard undergraduate. Melton expressed gratitude to both the Juvenile Diabetes Research Foundation and...
World’s first novel method for label-free identification of stem cells will lead to more consistent, efficacious stem cell therapies, experts say
With better identification of MSCs, doctors can be certain that the concentration of highly enriched MSC mixture is as stated, making it easier for them to develop stem- cell-based treatment that would be more consistent and produce better results. Dr Hui Shi said, “Our test in mice showed that MSCs can be identified and highly enriched for bone growth and muscle repair. This means that we can...
Cite This Page: In the current study, nine boys with SCID-X1 underwent gene therapy using a vector engineered by the study researchers. Seven boys developed functional T cells at levels comparable to those seen in previous studies and have remained healthy for one to three years after treatment. Analyses of the children’s T cells suggest that the new vector causes fewer genomic changes that...
Until now, there has been no good way to separate MSCs from bone marrow cells that have already begun to differentiate into other cell types, but share the same molecules on the cell surface. This may be one reason why research results vary among labs, and why stem-cell treatments now in clinical trials are not as effective as they could be, says Krystyn Van Vliet, an MIT associate professor of materials...
Tuszynski went on to state, “There are several important considerations that future studies will address. These include whether the extensive number of human axons make correct or incorrect connections; whether the new connections contain the appropriate chemical neurotransmitters to form functional connections; whether connections, once formed, are permanent or transient; and exactly how long...