Stem cell-based test predicts leukemia patients’ response to therapy to help tailor treatment

Stem cell-based test predicts leukemia patients' response to therapy to help tailor treatment
Leukemia researchers have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.

Genetic factors control regenerative properties of blood-forming stem cells

Genetic factors control regenerative properties of blood-forming stem cells
Two studies define how key genetic factors affect blood-forming stem cells by either accelerating or hindering the cells’ regenerative properties. The findings could one day lead to improved treatments for people undergoing common therapies for cancer such as chemotherapy and radiation, say researchers.

Leukemia drug combo is encouraging in early phase I clinical trial

Leukemia drug combo is encouraging in early phase I clinical trial
In a Phase I study, 8 out of 12 patients with relapsed and/or chemotherapy refractory blood cancers responded to a combination of the chemotherapy drugs thioguanine and decitabine; some of the responders had relapsed after treatment with decitabine alone, report researchers.

Preventative antibiotics could prevent Clostridium difficile infection among stem cell transplant patients

Preventative antibiotics could prevent Clostridium difficile infection among stem cell transplant patients
It may be possible to safely prevent one of the most common – and costly to treat – infections contracted by hospitalized patients undergoing bone marrow transplantation for the treatment of blood cancers, according to a new study.

New information on how brain cancer spreads

New information on how brain cancer spreads
Glioblastoma multiforme remains the most common and highly lethal brain cancer and is known for its ability to relapse. Researchers have identified a pathway by which cancer cells aggressively spread and grow in the brain, opening up new possibilities for treatment.

Possible explanation for recurring breast cancer

Possible explanation for recurring breast cancer
Many breast cancer survivors worry that their breast cancer may come back. Recurrence has puzzled scientists and health care providers, recognizing that it can suddenly reappear, often with a vengeance, months or years after treatment is over. Now, researchers have found that dormant tumor cells might have become latent because they cannibalized–basically ate–the body’s own stem cells....

Stem cell therapy appears to have TBI treatment effect

Stem cell therapy appears to have TBI treatment effect
Results of a cellular therapy clinical trial for traumatic brain injury (TBI) using a patient’s own stem cells showed that the therapy appears to dampen the body’s neuroinflammatory response to trauma and preserve brain tissue, according to researchers.

Discovery of molecular marker specific to early embryonic heart development

Discovery of molecular marker specific to early embryonic heart development
Researchers have identified a molecule specifically expressed on one of the first cell populations to emerge as a precursor of the heart in embryos, which enables the cells to be isolated and studied, and potentially transplanted as a treatment for heart failure.

New study suggests way to slow skin fibrosis in scleroderma

New study suggests way to slow skin fibrosis in scleroderma
A possible mechanism behind the fibrosis that occurs in scleroderma has now been identified, a mechanism, researchers say, that may one day lead to a treatment for the disease.

Study shows promise to repair the urethra using bone marrow stem cells

Study shows promise to repair the urethra using bone marrow stem cells
A potential new strategy may be utilized to correct hypospadias, a birth defect which occurs when boys are born with a urinary opening on the underside of the penis, found in up to one in every 200 boys. Current treatment involves surgical reconstruction with a graft using tissue taken from the inside of a child’s cheek. This approach is associated with multiple complications and sometimes requires...