‘Instant liver, just add water’? Not quite, but a better way to grow multiple organs

'Instant liver, just add water'? Not quite, but a better way to grow multiple organs
Pluripotent stem cells can be used to make experimental models of organ systems, but current techniques often produce models that bear limited resemblance to true organs. Researchers developed an improved method to make a sophisticated three-dimensional organoid model of the liver, pancreas, and bile ducts. The model may help researchers understand how these organs form and how genetic mutations can...

A compound effective to chemotherapy-resistant cancer cells identified

A compound effective to chemotherapy-resistant cancer cells identified
A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.

Embryo’s early development revealed in a dish

Embryo's early development revealed in a dish
Bioscientists develop a method to observe patterns of early embryonic development, during which ectodermal cells diverge toward their fates as skin, organs and the nervous system.

When added to gene therapy, plant-based compound may enable faster, more effective treatments

When added to gene therapy, plant-based compound may enable faster, more effective treatments
Today’s standard process for administering gene therapy is expensive and time-consuming — a result of the many steps required to deliver the healthy genes into the patients’ blood stem cells to correct a genetic problem. Scientists believe they have found a way to sidestep some of the current difficulties, resulting in a more efficient gene delivery method that would save money and...

Viagra shows promise for use in bone marrow transplants

Viagra shows promise for use in bone marrow transplants
Researchers have demonstrated a new, rapid method to obtain donor stem cells for bone marrow transplants using a combination of Viagra and a second drug called Plerixafor. Bone marrow transplants, used mostly in the treatment of cancer, are life-saving procedures to restore the stem cells that generate new blood cells throughout a person’s life.

First cell map of developing human liver reveals how blood and immune system develops

First cell map of developing human liver reveals how blood and immune system develops
In a world first, scientists have created the human developmental liver cell atlas that provides crucial insights into how the blood and immune systems develop in the fetus. It maps changes in the cellular landscape of the developing liver between the first and second trimesters of pregnancy, including how stem cells from the liver seed other tissues to support the high demand for oxygen needed for...

Potential liver cancer treatment by targeting cancer stem-like cells

Potential liver cancer treatment by targeting cancer stem-like cells
Researchers have shown the potential use of small molecule inhibitors to treat advanced liver cancer.

Treatment for ‘low T’ could someday come from a single skin cell

Treatment for 'low T' could someday come from a single skin cell
Researchers have successfully grown human, testosterone-producing cells in the lab, paving the way to someday treat low testosterone with personalized replacement cells.

New method to purify cell types to high purity

New method to purify cell types to high purity
Current biology research relies on the ability to purify cell types using antibodies or transgenic constructs. However, antibody availability is often limited, and genetic manipulation is labor intensive or sometimes impossible. To date, no universal method exists to enrich for cell types without a priori knowledge of cell type markers. Here, we propose GateID, a computational method that combines...

Stem cell studies offer hope for childhood neurological condition

Stem cell studies offer hope for childhood neurological condition
Two new studies report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.