Delivering proteins to testes could someday treat male infertility

Delivering proteins to testes could someday treat male infertility
According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame. Now, researchers have found a way to deliver a protein important for sperm cell production directly to mouse testicles, where it restored normal sperm development and allowed previously infertile mice to father pups....

Skeletal muscle development and regeneration mechanisms vary by gender

Skeletal muscle development and regeneration mechanisms vary by gender
Researchers have generated mice lacking the estrogen receptor beta gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. This was not observed in male mice that lacked the ER-beta gene, suggesting that estrogen and its downstream signals may be a female-specific mechanism for muscle growth and regeneration....

Damaged muscles don’t just die, they regenerate themselves

Damaged muscles don't just die, they regenerate themselves
Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate ”satellite cells,” which are muscle stem cells. While attempting to identify the activating proteins, they found that metabolic enzymes, such as GAPDH, rapidly activated quiescent satellite cells and accelerated muscle injury regeneration. This is a highly...

Researchers make counterintuitive discoveries about immune-like characteristics of cells

Researchers make counterintuitive discoveries about immune-like characteristics of cells
Biologists reveal that tissue perturbations by chemotherapy agents promote stem cell expansion and that fibroblast cells exhibit unexpected, immune-like behavior.

To make mini-organs grow faster, give them a squeeze

To make mini-organs grow faster, give them a squeeze
To make organoids grow faster, give them a squeeze, suggests a new study, which finds compressing cells, and crowding their contents, can coax them to grow and divide. The results may lead to faster way to grow artificial organs.

Hair loss might be prevented by regulating stem cell metabolism

Hair loss might be prevented by regulating stem cell metabolism
Medical researchers have identified a mechanism that is likely to prevent hair loss.

Stem cell sheets harvested in just two days

Stem cell sheets harvested in just two days
A team has developed a thermoresponsive nanotopography cell culture platform.

Coupling antibiotics with stem cells to fight off bone infections

Coupling antibiotics with stem cells to fight off bone infections
Researchers investigated the effects of adipose-derived stem cells (ADSCs) loaded with the antibiotic ciprofloxacin on osteomyelitis caused by implants. By administering ADSC-loaded ciprofloxacin to the site of bone infection in rats, the researchers found a significant improvement of the infection, as shown by reduced soft tissue swelling, abscess formation, and bone degradation. These findings suggest...

A small switch with a big impact

A small switch with a big impact
Minor changes in immune cells can significantly affect the immune response, scientists have now discovered. Their findings could be relevant for stem cell therapy.

Hormone that might help treat malabsorption identified

Hormone that might help treat malabsorption identified
Scientists at Cincinnati Children’s used human intestinal organoids grown from stem cells to discover how our bodies control the absorption of nutrients from the food we eat. They further found that one hormone might be able to reverse a congenital disorder in babies who cannot adequately absorb nutrients and need intravenous feeding to survive.