A ‘cardiac patch with bioink’ developed to repair heart

A 'cardiac patch with bioink' developed to repair heart
Medical researchers have developed an ‘in vivo priming’ with heart-derived bioink. Using engineered stem cells and 3D bioprinting technology, they began developing medicines for cardiovascular diseases.

New in vivo priming strategy to train stem cells can enhance cardiac repair effectiveness

New in vivo priming strategy to train stem cells can enhance cardiac repair effectiveness
A stem cell biologist from City University of Hong Kong (CityU), together with his collaborators, has developed a novel strategy, called in vivo priming, to ‘train’ the stem cells to stay strong after implantation to the damaged heart via the 3D-printed bandage-like patch. The positive results of the study show that an in vivo priming strategy can be an effective means to enhance cardiac...

For clogged and hardened hearts, a mussel is the solution

For clogged and hardened hearts, a mussel is the solution
Researchers have developed a stem cell therapy on myocardial infarction, using proteins that can be found in mussels, mussel adhesive proteins.

Modeling the human eye in a dish

Modeling the human eye in a dish
Researchers have developed and validated a novel PITX2-eGFP hiPSC reporter line to model the development of periocular mesenchymal cells. These findings could help understand how the eye develops during embryogenesis and how it changes during disease processes.

Advances in production of retinal cells for treating blindness

Advances in production of retinal cells for treating blindness
Researchers have discovered a way to refine the production of retinal cells from embryonic stem cells for treating blindness in the elderly. Using the CRISPR/Cas9 gene editing, they have also managed to modify the cells so that they can hide from the immune system to prevent rejection.

Hidden messages in protein blueprints

Hidden messages in protein blueprints
Scientists have identified a new control mechanism that enables stem cells to adapt their activity in emergency situations. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. In this way, they control the amount of protein produced and can also control the formation of certain proteinisoforms. If this mechanism is inactivated,...

Immunotherapy using ‘young cells’ offers promising option against cancer

Immunotherapy using 'young cells' offers promising option against cancer
A new study suggests that the age of certain immune cells used in immunotherapy plays a role in how effective it is. These cells — natural killer (NK) cells — appear to be more effective the earlier they are in development, opening the door to the possibility of an immunotherapy that would not utilize cells from the patient or a matched donor. Instead, they could be developed from existing...

How skin cells prepare to heal wounds

How skin cells prepare to heal wounds
Researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds. Results from the study provide a blueprint for future investigation into pathological conditions associated with poor wound healing, such as in diabetic patients.

Stem cells and nerves interact in tissue regeneration and cancer progression

Stem cells and nerves interact in tissue regeneration and cancer progression
Researchers show that different stem cell populations are innervated in distinct ways. Innervation may therefore be crucial for proper tissue regeneration. They also demonstrate that cancer stem cells likewise establish contacts with nerves. Targeting tumor innervation could thus lead to new cancer therapies.

Solving the riddle of superbug toxin damage to gut

Solving the riddle of superbug toxin damage to gut
Scientists have revealed that a bacterial superbug can prevent stem cells in the gut from carrying out their vital role of regenerating the inner lining of the intestine.