Solving a biological puzzle: How stress causes gray hair

Solving a biological puzzle: How stress causes gray hair
Scientists have found evidence to support long-standing anecdotes that stress causes hair graying. Researchers found that in mice, the type of nerve involved in the fight-or-flight response causes permanent damage to the pigment-regenerating stem cells in the hair follicle. The findings advance knowledge of how stress impacts the body, and are a first step toward blocking its negative effects.

Cancer study may accidentally help researchers create usable blood stem cells

Cancer study may accidentally help researchers create usable blood stem cells
A new study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort to make personalizable, durable blood stem cells.

Mutations in donors’ stem cells may cause problems for cancer patients

Mutations in donors' stem cells may cause problems for cancer patients
A new study suggests that extremely rare, harmful genetic mutations present in healthy donors’ stem cells — though not causing health problems in the donors — may be passed on to cancer patients receiving stem cell transplants, potentially creating health problems for the recipients. Among the concerns are heart damage, graft-versus-host disease and possible new leukemias.

Artificial muscle sheets transform stem cells into bone

Artificial muscle sheets transform stem cells into bone
Specifically programmed materials can, under specific conditions, encourage stem cells to transform into bone cells. To do this, scientists implemented a so-called shape-memory polymer in stem cell research.

Human immune cells produced in a dish in world first

Human immune cells produced in a dish in world first
A research team has reproduced and visualized the earliest developmental steps in human immune cell production in the laboratory and are now set to advance our understanding of childhood diseases like leukemia and autoimmune conditions.

Cellular clock regulating human spine development

Cellular clock regulating human spine development
After decades of effort, scientists use induced pluripotent stem cells to model human spine development. Findings provide proof of existence of a segmentation clock in humans guiding spine formation. Work sets stage for better understanding of musculoskeletal and metabolic disorders, including congenital scoliosis, muscular dystrophy and type 2 diabetes.

First genomic study of puberty yields insights into development and cancer

First genomic study of puberty yields insights into development and cancer
In the first-ever genome-scale analysis of the puberty process in humans, researchers outline distinct and critical changes to stem cells in males during adolescence.

New protocol to generate intestinal organoids in vitro

New protocol to generate intestinal organoids in vitro
Researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system. Using human induced pluripotent stem cells, this novel approach combined a variety of techniques that enabled the development of three-dimensional groups of intestinal cells called organoids...

Rejuvenating the brain with stem cells

Rejuvenating the brain with stem cells
The older we get the more our brains will find it difficult to learn and remember new things. The research group used a method to stimulate the small pool of neural stem cells that reside in the brain in order to increase their number and the number of neurons generated by those stem cells. Additional neurons could survive and form new contacts with neighboring cells in the brain of old mice.

Recurrent miscarriage: Diabetes drug could lead to new treatment

Recurrent miscarriage: Diabetes drug could lead to new treatment
A drug designed to tackle diabetes could also be repurposed as the first treatment to prevent miscarriage by targeting the lining of the womb itself, according to a clinical trial.