Hope for children with rare heart condition: novel stem cell therapy to save the day

Hope for children with rare heart condition: novel stem cell therapy to save the day
Researchers put forward a safe and efficient new stem cell therapy for regenerating cardiac function in pediatric patients.

SARS-CoV-2 infection demonstrated in a human lung bronchioalveolar tissue model

SARS-CoV-2 infection demonstrated in a human lung bronchioalveolar tissue model
Researchers have demonstrated that SARS-CoV-2 replicates efficiently in their model resembling the human bronchioalveolar system that is thought to play a critical role in progression of infection towards pneumonia and ARDS.

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation
The gut plays a central role in the regulation of the body’s metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach...

Discovery of aging mechanism for hematopoietic stem cells

Discovery of aging mechanism for hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells.

Growing human organs for transplantation with new proof-of-concept

Growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new article, researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs....

New insights into the mechanisms of neuroplasticity

New insights into the mechanisms of neuroplasticity
Scientists report that reactive oxygen molecules, also known as ‘free radicals,’ are important for the brain’s ability to adapt — at least in mice.

Oh so simple: Eight genes enough to convert mouse stem cells into oocyte-like cells

Oh so simple: Eight genes enough to convert mouse stem cells into oocyte-like cells
By activating just eight genes for transcription factors, researchers have directly converted mouse stem cells into oocyte-like cells that mature and can even be fertilized like egg cells. In addition to giving new insight into egg cell development, the research may lead to a simple route for generating large amounts of oocyte cytoplasm for use in reproductive biology and medicine.

The bull’s eye: New modified stem cells can deliver drugs specifically to tumor cells

The bull's eye: New modified stem cells can deliver drugs specifically to tumor cells
Targeting drugs to cancer tissues is a major challenge in cancer treatment. Mesenchymal stem cells (MSCs) are known for their ability to find and target tumor cells in the body, but using MSCs for drug delivery has been tricky, because upon loading with drugs, MSCs lose their viability and migratory ability. Now, researchers have successfully modified MSCs to deliver large quantities of anti-cancer...

New insights into Fragile X syndrome and the fetal brain

New insights into Fragile X syndrome and the fetal brain
Researchers have revealed further insight into the fetal development of our brain and the potential causes of Fragile X syndrome (FSX).

Research dispels fears human stem cells contain cancer-causing mutations

Research dispels fears human stem cells contain cancer-causing mutations
Pioneering new research has made a pivotal breakthrough that dispel concerns that human stem cells could contain cancer-causing mutations.